Arsenal and Liverpool will break new ground in their 115-year rivalry at the Emirates Stadium on Wednesday when they meet in European competition for the first time.
The Champions League quarterfinal first leg will be the 200th occasion the sides have clashed and although they have faced each other in FA Cup finals and a title decider in the past, few of the previous encounters have had as much at stake.
A place in the semifinals against Chelsea or Fenerbahce awaits the winners, with May's final in Moscow looming just over the horizon.
Wednesday's match is the first of three between the sides in seven days with a Premier League meeting at the Emirates on Saturday to follow before the return leg at Anfield on April 8.
Arsenal, buoyed by their gutsy 3-2 comeback win at Bolton Wanderers on Saturday when they overturned a 2-0 deficit with only 10 men, are set to recall Togolese striker Emmanuel Adebayor to the starting line-up.
However, Arsenal's defence, missing the injured Bacary Sagna, will need to watch Fernando Torres, who scored his 21st league goal of the season and 28th in all competitions against Everton on Sunday.
Lampard set to return
In the other quarterfinal tie in Istanbul, Fenerbahce takes on mighty Chelsea at home. Coach Zico says it is imperative Fenerbahce beat Chelsea in the first leg, adds Reuters. Frank Lampard should return after a stomach upset. Goalkeeper Petr Cech is doubtful with an ankle injury but Didier Drogba is expected to be fit after picking up a knock at the weekend.