In bookstores, the science aisle generally lies well away from the self-help section, with hard reality on one set of shelves and wishful thinking on the other. But Norman Doidge's fascinating synopsis of the current revolution in neuroscience, "The Brain That Changes Itself: Stories of Personal Triumph From the Frontiers of Brain Science," straddles this gap: the age-old distinction between the brain and the mind is crumbling fast as the power of positive thinking finally gains scientific credibility.
The credo of this revolution is neuroplasticity -- the discovery that the human brain is as malleable as a lump of wet clay not only in infancy, as scientists have long known, but well into hoary old age.
In classical neuroscience, the adult brain was considered an immutable machine, as wonderfully precise as a clock in a locked case. Every part had a specific purpose, none could be replaced or repaired, and the machine was destined to tick in unchanging rhythm until its gears corroded with age.
Now sophisticated experimental techniques suggest the brain is more like a Disney-esque animated sea creature. Constantly oozing in various directions, it is apparently able to respond to injury with striking functional reorganization, and can at times actually think itself into a new anatomic configuration, in a kind of word-made-flesh outcome far more characteristic of Lourdes than the National Institutes of Health.
So it is forgivable that Doidge, a Canadian psychiatrist and award-winning science writer, recounts the accomplishments of the "neuroplasticians," as he calls the neuroscientists involved in these new studies, with breathless reverence. Their work is indeed mind-bending, miracle-making, reality-busting stuff, with implications, as Doidge notes, not only for individual patients with neurologic disease but for all human beings, not to mention human culture, human learning and human history.
For patients with brain injury, the revolution brings only good news, as Doidge describes in numerous examples. A woman with damage to the inner ear's vestibular system, where the sense of balance resides, feels as if she is in constant free fall, tumbling through space like an ocean bather pulled under by the surf.
Sitting in a neuroscience lab, she puts a set of electrodes on the surface of her tongue, a wired-up hard hat on her head, and the feel of falling stops. The apparatus connects to a computer to create an external vestibular system, replacing her damaged one by sending the proper signals to her brain via her tongue.
But that's not all. After a year of sessions with the device, she no longer needs it: her brain has rewired itself to bypass the damaged vestibular system with a new circuit.
A surgeon in his 50s suffers an incapacitating stroke. He is one of the first patients to enroll in a rehabilitation clinic guided by principles of neuroplasticity: his good arm and hand are immobilized, and he is set cleaning tables. At first the task is impossible, then slowly the bad arm remembers its skills. He learns to write again, he plays tennis again: the functions of the brain areas killed in the stroke have transferred themselves to healthy regions.
An amputee has a bizarre itch in his missing hand: unscratchable, it torments him. A neuroscientist finds that the brain cells that once received input from the hand are now devoted to the man's face; a good scratch on the cheek relieves the itch.  Research into the malleability of the normal brain has been no less amazing. Subjects who learn to play a sequence of notes on the piano develop characteristic changes in the brain's electric activity; when other subjects sit in front of a piano and just think about playing the same notes, the same changes occur. It is the virtual made real, a solid quantification of the power of thought.
Neuroplasticity may prove a curse as well. The brain can think itself into ruts, with electrical habits as difficult to eradicate as if it were, in fact, the immutable machine of yore. And, of course, the implications for external re-engineering of the human brain are ominous, for if the brain is malleable it is also endlessly vulnerable.