Press Esc to close
Thursday 27 April 2017
News updated at 1:08 AM IST

'Ketogenic diet' can ward off ageing: Study

Washington, Dec 7, 2012, PTI: 22:14 IST
A type of low-carb, low-calorie diet called “ketogenic diet” is rich in a compound that could delay the effects of ageing, scientists say.

Researchers in the laboratory of Gladstone Senior Investigator Eric Verdin, have identified the role that a chemical compound in the human body plays in the ageing process.

The mechanism may be key to new therapies for treating or preventing a variety of age-related diseases, including heart disease, Alzheimer’s and many forms of cancer.

Researchers examined the role of the compound beta-hydroxybutyrate (beta-OHB), a so-called “ketone body” produced during a prolonged low-calorie or ketogenic diet.

While ketone bodies such as beta-OHB can be toxic when present at very high concentrations in people with diseases such as Type I diabetes, researchers found that at lower concentrations, beta-OHB helps protect cells from “oxidative stress” — which occurs as certain molecules build to toxic levels in the body and contributes to the ageing process.

“Here, we find that beta-OHB - the body’s major source of energy during exercise or fasting - blocks a class of enzymes that would otherwise promote oxidative stress, thus protecting cells from ageing,” Verdin said in a statement.

Oxidative stress occurs as cells use oxygen to produce energy, but this activity also releases other potentially toxic molecules, known as free radicals.

As cells age, they become less effective in clearing these free radicals — leading to cell damage, oxidative stress and the effects of ageing. Researchers found that beta-OHB might actually help delay this process.

In a series of laboratory experiments, the team administered beta-OHB in a chronic calorie-restricted diet.

The researchers found that calorie restriction spurs beta-OHB production, which blocked the activity of a class of enzymes called histone deacetylases, or HDACs.

Normally HDACs keep a pair of genes, called Foxo3a and Mt2, switched off, but increased levels of beta-OHB block the HDACs from doing so, which by default activates the two genes.

Once activated, these genes kick-start a process that helps cells resist oxidative stress. This discovery not only identifies a novel signalling role for beta-OHB, but it could also represent a way to slow the detrimental effects of ageing in all cells of the body.

Go to Top

Photo Gallery
Priyanka Chopra at a promotional event for her upcoming film ‘Baywatch’ in Mumbai on Wednesday...

Priyanka Chopra at a promotional event for her upcoming film ‘Baywatch’ in Mumbai on Wednesday...

Maria Sharapova at a training session at the WTA Porsche Tennis Grand Prix in Stuttgart, Germany...

Maria Sharapova at a training session at the WTA Porsche Tennis Grand Prix in Stuttgart, Germany...

A cake weighing 30 kg is cut as part of celebrations outside BSE as Sensex ended above the...

A cake weighing 30 kg is cut as part of celebrations outside BSE as Sensex ended above the...

Family members of CRPF jawan Naresh Yadav, mourn in Darbhanga on Wednesday. He was martyred in...

Family members of CRPF jawan Naresh Yadav, mourn in Darbhanga on Wednesday. He was martyred in...

Soldiers of the Arctic motorised rifle brigade of Russia's Northern Fleet stand near APCs...

Soldiers of the Arctic motorised rifle brigade of Russia's Northern Fleet stand near APCs...

Blossoming apple trees are covered in snow near Altenstadt, Germany...

Blossoming apple trees are covered in snow near Altenstadt, Germany...

A watermelon vendor takes a nap on a hot day in Chennai on Wednesday...

A watermelon vendor takes a nap on a hot day in Chennai on Wednesday...

A boy jumps into the river Ganga to beat the heat in Kolkata on Wednesday...

A boy jumps into the river Ganga to beat the heat in Kolkata on Wednesday...

A newly-built aircraft carrier is transferred from dry dock into the water at a launch ceremony...

A newly-built aircraft carrier is transferred from dry dock into the water at a launch ceremony...

U.S. Army's M1 A2 tanks fire during the South Korea-U.S. joint military live-fire drills...

U.S. Army's M1 A2 tanks fire during the South Korea-U.S. joint military live-fire drills...

Like us on Facebook

Copyright 2017, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523
Powered by Yodasoft Technologies Pvt. Ltd.