Press Esc to close
Tuesday 27 June 2017
News updated at 8:38 AM IST

'Ketogenic diet' can ward off ageing: Study

Washington, Dec 7, 2012, PTI: 22:14 IST
A type of low-carb, low-calorie diet called “ketogenic diet” is rich in a compound that could delay the effects of ageing, scientists say.

Researchers in the laboratory of Gladstone Senior Investigator Eric Verdin, have identified the role that a chemical compound in the human body plays in the ageing process.

The mechanism may be key to new therapies for treating or preventing a variety of age-related diseases, including heart disease, Alzheimer’s and many forms of cancer.

Researchers examined the role of the compound beta-hydroxybutyrate (beta-OHB), a so-called “ketone body” produced during a prolonged low-calorie or ketogenic diet.

While ketone bodies such as beta-OHB can be toxic when present at very high concentrations in people with diseases such as Type I diabetes, researchers found that at lower concentrations, beta-OHB helps protect cells from “oxidative stress” — which occurs as certain molecules build to toxic levels in the body and contributes to the ageing process.

“Here, we find that beta-OHB - the body’s major source of energy during exercise or fasting - blocks a class of enzymes that would otherwise promote oxidative stress, thus protecting cells from ageing,” Verdin said in a statement.

Oxidative stress occurs as cells use oxygen to produce energy, but this activity also releases other potentially toxic molecules, known as free radicals.

As cells age, they become less effective in clearing these free radicals — leading to cell damage, oxidative stress and the effects of ageing. Researchers found that beta-OHB might actually help delay this process.

In a series of laboratory experiments, the team administered beta-OHB in a chronic calorie-restricted diet.

The researchers found that calorie restriction spurs beta-OHB production, which blocked the activity of a class of enzymes called histone deacetylases, or HDACs.

Normally HDACs keep a pair of genes, called Foxo3a and Mt2, switched off, but increased levels of beta-OHB block the HDACs from doing so, which by default activates the two genes.

Once activated, these genes kick-start a process that helps cells resist oxidative stress. This discovery not only identifies a novel signalling role for beta-OHB, but it could also represent a way to slow the detrimental effects of ageing in all cells of the body.

Go to Top

Photo Gallery
A black kite flies past during Sunrise in New Delhi...

A black kite flies past during Sunrise in New Delhi...

Bollywood actress Kajol with Soundarya and Dhanush during the trailer launch of film VIP 2...

Bollywood actress Kajol with Soundarya and Dhanush during the trailer launch of film VIP 2...

Pakistani women greet each others after the Eid al-Fitr prayers...

Pakistani women greet each others after the Eid al-Fitr prayers...

A Barbary lion cub, stands next to its father 'Schroeder' at the zoo in Neuwied, Germany...

A Barbary lion cub, stands next to its father 'Schroeder' at the zoo in Neuwied, Germany...

Winners of 8th Men Mega Mr. North East and 15th Miss North East 2017, Mary Khemlang (Center)...

Winners of 8th Men Mega Mr. North East and 15th Miss North East 2017, Mary Khemlang (Center)...

Bollywood actors Huma Qureshi and Dhanush during the trailer launch of film VIP 2 Lalkar...

Bollywood actors Huma Qureshi and Dhanush during the trailer launch of film VIP 2 Lalkar...

Muslims offering namaz at historical Taj Mahal on the occasion of Eid-ul-Fitr...

Muslims offering namaz at historical Taj Mahal on the occasion of Eid-ul-Fitr...

Obama and his family arrived last week on the resort island for a vacation...

Obama and his family arrived last week on the resort island for a vacation...

Smoke rises from the ground by charred trees near the access to the Cuesta Maneli beach...

Smoke rises from the ground by charred trees near the access to the Cuesta Maneli beach...

President Pranab Mukherjee receiving Eid greetings from various groups of people...

President Pranab Mukherjee receiving Eid greetings from various groups of people...

Like us on Facebook

Copyright 2017, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523
Powered by Yodasoft Technologies Pvt. Ltd.