Press Esc to close
Saturday 01 October 2016
News updated at 2:20 AM IST
Weather
Max: 29.7°C
Min : 20.5°C
In Bengaluru
Generally cloudy

GM tobacco plant can treat rabies

London, Feb 3, 2013 (PTI):

A genetically altered version of the tobacco plant may provide an inexpensive cure for the deadly rabies virus to patients in developing countries, scientists say.

In a new research reported in the FASEB Journal, scientists produced a monoclonal antibody in transgenic tobacco plants that was shown to neutralise the rabies virus.
The new antibody works by preventing the virus from attaching to nerve endings around the bite site and keeps the virus from travelling to the brain.

“Rabies continues to kill many thousands of people throughout the developing world every year and can also affect international travellers,” said Leonard Both, a researcher involved in the work from the Hotung Molecular Immunology Unit at St George’s, University of London, in the UK.

“An untreated rabies infection is nearly 100 per cent fatal and is usually seen as a death sentence. Producing an inexpensive antibody in transgenic plants opens the prospect of adequate rabies prevention for low-income families in developing countries,” Both said in a statement.

Both and colleagues “humanised” the sequences for the antibody so people could tolerate it. Then, the antibody was produced using transgenic tobacco plants as an inexpensive production platform.

The antibody was purified from the plant leaves and characterised with regards to its protein and sugar composition.

The antibody was also shown to be active in neutralising a broad panel of rabies viruses, and the exact antibody docking site on the viral envelope was identified using certain chimeric rabies viruses.

“Although treatable by antibodies if caught in time, rabies is bad news,” said Gerald Weissmann, Editor-in-Chief of the FASEB Journal.

“This is especially true for people in the developing world where manufacturing costs lead to treatment shortages. Being able to grow safe, humanised antibodies in genetically modified tobacco should reduce costs to make treatments more accessible, and save more lives,” Weissmann said.


Go to Top

Photo Gallery
A hair stylist Kailash Kashid creates a special hair cut slogan of Maratha Kranti Morcha...

A hair stylist Kailash Kashid creates a special hair cut slogan of Maratha Kranti Morcha...

Actor Salman Khan plays with his sister Arpita's kid at an event for the tie-up between...

Actor Salman Khan plays with his sister Arpita's kid at an event for the tie-up between...

Artisans work on a giant model of Hindu god Ganesh during preparations for the upcoming Durga Puja..

Artisans work on a giant model of Hindu god Ganesh during preparations for the upcoming Durga Puja..

The palace witnessed very little visitors on the day and thus children enjoy playing at the...

The palace witnessed very little visitors on the day and thus children enjoy playing at the...

Temples submerged at Gwari Ghat due to floods caused in Narmada River by heavy rains...

Temples submerged at Gwari Ghat due to floods caused in Narmada River by heavy rains...

Indian Army vehicles move towards border areas in Akhnoor sector on India Pakistan Border...

Indian Army vehicles move towards border areas in Akhnoor sector on India Pakistan Border...

BJP activists celebrate the Indian army's Surgical strikes along the Line of Control in PoK...

BJP activists celebrate the Indian army's Surgical strikes along the Line of Control in PoK...

all-party meeting in New Delhi on Thursday following Indian army's surgical strikes along the LoC...

all-party meeting in New Delhi on Thursday following Indian army's surgical strikes along the LoC...

People celebrate after Indian army's Surgical strikes along the Line of Control...

People celebrate after Indian army's Surgical strikes along the Line of Control...

Artists practice the Garba dance ahead of the Navratri festival in Ahmedabad...

Artists practice the Garba dance ahead of the Navratri festival in Ahmedabad...

Copyright 2014, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523