Press Esc to close
Friday 27 February 2015
News updated at 6:42 PM IST
Weather
Max: 31.7°C
Min : 16.9°C
In Bengaluru
clear sky

Three billion-year-old proteins resurrected

Washington, Feb 28, 2013, (IANS):

Scientists have resurrected two to three billion-year-old proteins from which the enzymes that armour superbugs against antibiotics have descended.

The achievement opens the door to a scientific "replay" of the evolution of antibiotic resistance with an eye to finding new ways to cope with the problem.

Jose M. Sanchez-Ruiz, Valeria A. Risso, from the University of Granada, Spain and Eric A. Gaucher, Georgia Institute of  Technology explain that antibiotic resistance existed long before Alexander Fleming discovered the first antibiotic in 1928, the Journal of the American Chemical Society reports.

Genes that contain instructions for making the proteins responsible for antibiotic resistance have been found in  30,000-year-old permafrost sediment and other ancient sites, according to a Granada and Georgia statement.

Their research focused on the so-called beta-lactamases, enzymes responsible for resistance to the family of antibiotics that includes penicillin, which scientists believe originated billions of years ago.

Risso, Sanchez-Ruiz Gaucher used lab and statistical techniques to reconstruct the sequences of beta-lactamase proteins dating to Precambrian times, two to three billion years ago.

The team also synthesised the inferred ancestral enzymes and conducted studies on their stability, structure and function.
"The availability of laboratory resurrections of Precambrian beta-lactamases opens up new possibilities in the study of the emergence of antibiotic resistance," the  report states.

The study co-authors also note that the extreme stability and catalytic features displayed by the two-three-billion-year-old lactamases suggest that resurrected Precambrian proteins have utility for the biotechnology industry.


Go to Top

Photo Gallery
RJD chief Lalu Prasad Yadav performs ritual at the marriage of his daughter Raj Laxmi with Tej Prat

RJD chief Lalu Prasad Yadav performs ritual at the marriage of his daughter Raj Laxmi with Tej Prat

Activists shout patriotic slogans as they pay tributes to the freedom-fighter Chandrashekhar Azad

Activists shout patriotic slogans as they pay tributes to the freedom-fighter Chandrashekhar Azad

Foreign delegates pose for a group photo at Parliament House

Foreign delegates pose for a group photo at Parliament House

Swine Flu vaccination program at a school in Bikaner

Swine Flu vaccination program at a school in Bikaner

Anna Hazare joins farmers' protest

Anna Hazare joins farmers' protest

Crime Branch seizes fake currency worth more than Rs 2.5 Lakhs

Crime Branch seizes fake currency worth more than Rs 2.5 Lakhs

Memebers in the Lok Sabha during the Budget session

Memebers in the Lok Sabha during the Budget session

Students march and light flares during the second day of student strike in Madrid, Spain...

Students march and light flares during the second day of student strike in Madrid, Spain...

Indian Weightlifter Kailash Sarma and Modhusmrita Baruah displaying their gold medals...

Indian Weightlifter Kailash Sarma and Modhusmrita Baruah displaying their gold medals...

Bollywood actor Shatrughan Sinha and singer Sonu Nigam during the success party of the later's album

Bollywood actor Shatrughan Sinha and singer Sonu Nigam during the success party of the later's album

Copyright 2014, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523