Press Esc to close
Saturday 20 December 2014
News updated at 7:51 AM IST
Weather
Max: 24°C
Min : 18.2°C
In Bengaluru
Generally cloudy

Three billion-year-old proteins resurrected

Washington, Feb 28, 2013, (IANS):

Scientists have resurrected two to three billion-year-old proteins from which the enzymes that armour superbugs against antibiotics have descended.

The achievement opens the door to a scientific "replay" of the evolution of antibiotic resistance with an eye to finding new ways to cope with the problem.

Jose M. Sanchez-Ruiz, Valeria A. Risso, from the University of Granada, Spain and Eric A. Gaucher, Georgia Institute of  Technology explain that antibiotic resistance existed long before Alexander Fleming discovered the first antibiotic in 1928, the Journal of the American Chemical Society reports.

Genes that contain instructions for making the proteins responsible for antibiotic resistance have been found in  30,000-year-old permafrost sediment and other ancient sites, according to a Granada and Georgia statement.

Their research focused on the so-called beta-lactamases, enzymes responsible for resistance to the family of antibiotics that includes penicillin, which scientists believe originated billions of years ago.

Risso, Sanchez-Ruiz Gaucher used lab and statistical techniques to reconstruct the sequences of beta-lactamase proteins dating to Precambrian times, two to three billion years ago.

The team also synthesised the inferred ancestral enzymes and conducted studies on their stability, structure and function.
"The availability of laboratory resurrections of Precambrian beta-lactamases opens up new possibilities in the study of the emergence of antibiotic resistance," the  report states.

The study co-authors also note that the extreme stability and catalytic features displayed by the two-three-billion-year-old lactamases suggest that resurrected Precambrian proteins have utility for the biotechnology industry.


Go to Top

Photo Gallery
People takes protection against cold with woollens...

People takes protection against cold with woollens...

helicopter following a crash during the men's World Cup Downhill skiing...

helicopter following a crash during the men's World Cup Downhill skiing...

a migrant carries a tent trough a field...

a migrant carries a tent trough a field...

King penguins stand on the edge of their tank ...

King penguins stand on the edge of their tank ...

Mount Gamalama spews volcanic ash as it erupts...

Mount Gamalama spews volcanic ash as it erupts...

Kashmiri students wearing shrouds with red colour

Kashmiri students wearing shrouds with red colour

Staff dressed as Santa Claus try to squeeze into a car at a theme...

Staff dressed as Santa Claus try to squeeze into a car at a theme...

The VIP flyover wears a deserted look during Taxi strike in Kolkata...

The VIP flyover wears a deserted look during Taxi strike in Kolkata...

Children during a Christmas celebration at National Centre for Performing Arts ...

Children during a Christmas celebration at National Centre for Performing Arts ...

Hero Action Team during a cycling expedition at Kufri...

Hero Action Team during a cycling expedition at Kufri...

Copyright 2014, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523