Press Esc to close
Friday 31 July 2015
News updated at 2:51 PM IST
Weather
Max: 21°C
Min : 33°C
In Bengaluru
Partially cloudy

Brain's 'garbage truck' may hold key to treating Alzheimer's

New York, June 29, 2013, (PTI)
File Photo.

Scientists have found that a newly discovered system by which the brain removes waste can act as a potentially powerful new tool to treat neurological disorders like Alzheimer's disease.

Researchers at University of Rochester Medical Center (URMC) in New York believe that some of the neurological disorders may arise when the system is not doing its job properly.

"Essentially all neurodegenerative diseases are associated with the accumulation of cellular waste products," said Maiken Nedergaard, co-director of the URMC Center for Translational Neuromedicine and author of the article in journal Science.

"Understanding and ultimately discovering how to modulate the brain's system for removing toxic waste could point to new ways to treat these diseases," Nedergaard said.

The complex network of waste removal, which researchers have dubbed the glymphatic system, was first disclosed by URMC scientists last August in the journal Science Translational Medicine.

While the discovery of the glymphatic system solved a mystery that had long baffled the scientific community, understanding how the brain removes waste – both effectively and what happens when this system breaks down – has significant implications for the treatment of neurological disorders.

Understanding what role the glymphatic system plays in the brain's inability to break down and remove beta amyloid could point the way to new treatments, researchers said.
Specifically, it can be investigated whether certain key 'players' in the glymphatic system, such as astrocytes, can be manipulated to ramp up the removal of waste.

"The idea that 'dirty brain' diseases like Alzheimer may result from a slowing down of the glymphatic system as we age is a completely new way to think about neurological disorders," said Nedergaard.

"It also presents us with a new set of targets to potentially increase the efficiency of glymphatic clearance and, ultimately, change the course of these conditions," he said.


Go to Top

Photo Gallery
A municipal worker fumigates submerged huts situated in the flooded banks of river Sabarmati in ...

A municipal worker fumigates submerged huts situated in the flooded banks of river Sabarmati in ...

A huge whale was found dead on the shores of the beach near Sister Fatima Church at Tannerbhavi ...

A huge whale was found dead on the shores of the beach near Sister Fatima Church at Tannerbhavi ...

School children and their teachers pay tribute to former President APJ Abdul Kalam in Moradabad ...

School children and their teachers pay tribute to former President APJ Abdul Kalam in Moradabad ...

The winning team of the UBA India Pro Basketball League 2015, Chennai Slam with the trophy after ...

The winning team of the UBA India Pro Basketball League 2015, Chennai Slam with the trophy after ...

An Indian boy dressed as Hindu god Shiva to attract alms from devotees chats with tourists as ...

An Indian boy dressed as Hindu god Shiva to attract alms from devotees chats with tourists as ...

People offer flower petals on the grave of former President A.P.J. Abdul Kalam during his funeral ..

People offer flower petals on the grave of former President A.P.J. Abdul Kalam during his funeral ..

1993 Mumbai blast convict Yakub Memon's brothers Suleiman and Usman sitting inside the car

1993 Mumbai blast convict Yakub Memon's brothers Suleiman and Usman sitting inside the car

People worship a bull during Bendur festival in Sangli on Wednesday...

People worship a bull during Bendur festival in Sangli on Wednesday...

Fire brigade and NDRF personnel rescue a person stuck in the three floor Matru-Chhaya...

Fire brigade and NDRF personnel rescue a person stuck in the three floor Matru-Chhaya...

Students of Patna Women's College wear tiger masks to create awareness to save tigers...

Students of Patna Women's College wear tiger masks to create awareness to save tigers...

Copyright 2014, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523