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The ill-effects of toxic chemicals

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Last Updated 18 July 2016, 18:40 IST

Everyday, children and adults are exposed to a variety of chemicals found in common household items. Now a growing body of research suggests that many of these chemicals — which are used to make plastic more flexible and upholstery less flammable — may also pose a threat to the developing brain. While the link between early chemical exposure and neurodevelopment disorders in children remains a matter of scientific debate, a coalition of top doctors, scientists and health advocates is calling for more aggressive regulation. The goal is to protect expectant mothers, infants and children from neurotoxic chemicals by stepping up efforts to curb air pollution, remediate old lead pipes, phase out certain pesticides, ban endocrine-disrupting chemicals used in food packaging and plastics and come up with a plan for getting rid of furniture laden with fire retardants.

The scientists note that neurodevelopmental disorders are complex and have multiple genetic, social and environmental causes. But most chemicals in use today were not adequately tested for safety before being allowed on the market, said Dr Jeanne Conry, an obstetrician-gynecologist and a past president of the American College of Obstetricians and Gynecologists, which is part of the coalition. “Before we can prescribe medicine, we have to prove it’s safe,” she said. “So, how come with the chemical industry, we assume everything is safe and have to prove there’s harm?”

Three weeks ago, the coalition endorsed a first-of-its-kind consensus statement called Project Tendr, which stands for Targeting Environmental NeuroDevelopmental Risks. The statement was published in the scientific journal Environmental Health Perspectives, and related articles are being published over the next few months in endocrinology, nursing, pediatrics and epidemiology journals. “We, as a society, should be able to take protective action when scientific evidence indicates a chemical is of concern, and not wait for unequivocal proof that a chemical is causing harm to our children,” the statement says.

The call for action comes just one week after the US president Barack Obama signed into a law a much-debated overhaul of the nation’s 40-year-old toxic chemical rules. Critics say the changes do not go far enough, and the plan for testing some 64,000 chemicals is far too slow — just 20 chemicals at a time. And the new law does not cover pesticides, one of the largest sources of childhood chemical exposures.

An official with the American Chemistry Council, which represents companies that make flame retardants, plastics and phthalates, said the new law already addresses the concerns raised by the Tendr coalition. The rules give more authority to the Environmental Protection Agency and require it to take into account vulnerable populations like pregnant women, children and older people, she said.

The Tendr coalition includes pediatric neurologists, several minority physician associations, nurses, learning disability advocacy groups, environmental organisations and the Endocrine Society. Linda Birnbaum, director of the National Institute of Environmental Health Sciences and the National Toxicology Program, has also signed the statement. The bottom line: The group wants the chemical industry to prove a chemical is safe, rather than waiting on the medical and scientific community to prove it is harmful.
“We’re saying, shift the burden of proof,” Jeanne said. Wading into a potentially contentious issue like regulation of chemicals is unusual for the ACOG, but the group has been alarmed by rising rates of neurodevelopmental disorders and
other health problems in children.

Researchers say changes in diagnostic criteria and a greater awareness of developmental disorders including autism, attention deficit disorders and other learning disabilities may explain some of the increase in rates but not all of it. The chemicals singled out by the coalition include:

*Organophosphate pesticides: In one study, women who were pregnant when they lived near areas where these pesticides were in use were as many as three times more likely to have a child who developed autism or other developmental disorders. Janet Collins, a senior vice president at CropLife America, which represents pesticide manufacturers, said the studies show only an association between pesticide levels and autism disorders, not a cause-and-effect relationship.

*Flame retardants: Recent studies have found that children exposed prenatally to higher levels of flame retardants had lower IQs. Flame retardants are used in fabric and upholstery padding, computers and baby products.

*Lead: The government has banned leaded gasoline and household paint, but old homes and pipes often still contain lead that gathers in dust and leaches into water. No level of exposure is considered safe.

*Phthalates: Prenatal exposure has been linked in studies to problems with attention and intellectual deficits. The Consumer Product Safety Commission has banned the use of six phthalates in toys and child care products, but they are still used in all kinds of consumer products.

*Combustion-related air pollutants: Prenatal and early childhood exposure to some pollutants has been linked with preterm birth and low birth weight, as well as developmental delays.

“The goal is not to demonise every chemical on the market,” said Heather B Patisaul, a professor at North Carolina State University at Raleigh. “We need to find the group that are harmful, and figure out why, and develop new chemicals that are significantly less harmful.”

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(Published 18 July 2016, 16:29 IST)

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