"Eight people died at the scene and another two" died at local hospitals, said Victor Lira, director of the area's Civil Protection agency, adding that some of the wounded were in a critical condition.
The head of the city's firefighters, William Martinez, said the truck appeared to have lost control and struck the back of the bus, pushing it onto the median where it flipped over.
Authorities have launched an investigation to determine whether excessive speeding or a brake failure may have caused the crash.
Last weekend, at least 24 people died in two traffic accidents on Venezuela's chaotic freeways.
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