<p> Sperm need to crane their necks to turn right to counteract a left-turning drive caused by the rotation of their tails, a finding that could improve in-vitro fertilisation (IVF) and fertility treatments, scientists say.<br /><br /></p>.<p>Researchers at the University of Warwick in London discovered that all sperm tails (flagella) rotate in a counter-clockwise motion as they beat to enable them to move through and against the motion of a fluid.<br /><br />The counter-clockwise motion means that sperm should only be able to move in a leftwards direction, but the researchers observed that approximately 50 per cent of the sperm observed in the research moved to the right.<br /><br />Comprised of a head, mid connecting piece and the flagella, 3D motion analysis of the sperm found that they were distorting their bodies at the mid-piece to counteract the physical forces that would cause them to turn left.<br /><br />The differences between the actions necessary for a sperm to turn left or right means that all could be able to turn in both directions or only one; indicating that there could be two physiologically distinct spermatozoa subpopulations.<br /><br />"We recently have learned that the sperm swim primarily near surfaces, which turned to be crucial for understanding why they navigate against a fluid flow," said Vasily Kantsler of the University of Warwick who led the study.<br /><br />"Analysing the 3D details of how a sperm's flagella beat, we have realised that all the cells rotate their flagella anti-clockwise, which would make them to turn left only," he added.<br /><br />"At the same time we have noticed the right moving sperm also have a right bent in the mid-piece section of the flagella providing a force, which would counteract the left-turning," Kantsler said.<br /><br />The researchers devised an experiment to understand sperm cell behaviour under peristaltic conditions, such as the flow caused by the contraction and relaxation of muscles.<br /><br />Something similar happens in a human fertility tract after insemination, where peristaltic contractions move the fluid back and forth providing an advantage for sperm propagation.<br /><br />The researchers observed 'heart' shape trajectories of sperm cells in the experiments, showing the sperm turning left or right against the flow to form half of a heart shape depending on the direction they took.<br /><br />This finding motivated the researchers to deeply analyse the 3D motion of spermatozoa flagella at high spatial and temporal resolution, something which had never been done before leading to the discovery of a mechanism distinguishing two different modes of the spermatozoa motion.<br /><br />The findings were published in the journal PNAS.</p>
<p> Sperm need to crane their necks to turn right to counteract a left-turning drive caused by the rotation of their tails, a finding that could improve in-vitro fertilisation (IVF) and fertility treatments, scientists say.<br /><br /></p>.<p>Researchers at the University of Warwick in London discovered that all sperm tails (flagella) rotate in a counter-clockwise motion as they beat to enable them to move through and against the motion of a fluid.<br /><br />The counter-clockwise motion means that sperm should only be able to move in a leftwards direction, but the researchers observed that approximately 50 per cent of the sperm observed in the research moved to the right.<br /><br />Comprised of a head, mid connecting piece and the flagella, 3D motion analysis of the sperm found that they were distorting their bodies at the mid-piece to counteract the physical forces that would cause them to turn left.<br /><br />The differences between the actions necessary for a sperm to turn left or right means that all could be able to turn in both directions or only one; indicating that there could be two physiologically distinct spermatozoa subpopulations.<br /><br />"We recently have learned that the sperm swim primarily near surfaces, which turned to be crucial for understanding why they navigate against a fluid flow," said Vasily Kantsler of the University of Warwick who led the study.<br /><br />"Analysing the 3D details of how a sperm's flagella beat, we have realised that all the cells rotate their flagella anti-clockwise, which would make them to turn left only," he added.<br /><br />"At the same time we have noticed the right moving sperm also have a right bent in the mid-piece section of the flagella providing a force, which would counteract the left-turning," Kantsler said.<br /><br />The researchers devised an experiment to understand sperm cell behaviour under peristaltic conditions, such as the flow caused by the contraction and relaxation of muscles.<br /><br />Something similar happens in a human fertility tract after insemination, where peristaltic contractions move the fluid back and forth providing an advantage for sperm propagation.<br /><br />The researchers observed 'heart' shape trajectories of sperm cells in the experiments, showing the sperm turning left or right against the flow to form half of a heart shape depending on the direction they took.<br /><br />This finding motivated the researchers to deeply analyse the 3D motion of spermatozoa flagella at high spatial and temporal resolution, something which had never been done before leading to the discovery of a mechanism distinguishing two different modes of the spermatozoa motion.<br /><br />The findings were published in the journal PNAS.</p>