New insight into control of body sugar

Scientists at the University of Leicester have discovered the part played by a particular protein in helping to maintain correct blood sugar levels.

The breakthrough was made by the team led by Professor Andrew Tobin, Professor of Cell Biology, a university release said.

The research is published online ahead of print in the prestigious international scientific journal the Proceedings of the National Academy of Sciences.

Professor Tobin said: "The work, which was done wholly at the University of Leicester, is focused on the mechanisms by which our bodies control the level of sugar in our blood following a meal."

"We found that in order to maintain the correct levels of sugar, a protein present on the cells that release insulin in the pancreas has to be active," he said.

The protein, called "the M3-muscarinic receptor, is not only active but also needs to undergo a specific change."

"This change triggers insulin release and the control of blood sugar levels,"  Tobin said.
He said without the change in the M3-muscarinic receptor protein sugar levels go up in the same way that we see in diabetes.

"We are of course testing if the mechanism of controlling sugar levels we have discovered is one of the mechanisms disrupted in diabetes. If this were the case then our studies would have important implications in diabetes," he underlined.

Comments (+)