JOIN USPietersen ruled out of entire series
The 29-year-old right-hander had surgery on the Achilles tendon injury which hampered him during the second test and he has been ruled out of all cricket for six weeks.
"Following a consultation, involving scans and testing, with the world's leading Achilles specialist Kevin Pietersen today underwent surgery on his right Achilles tendon," the England and Wales Cricket Board's chief medical officer Nick Peirce said in a statement.
"Kevin will look to undertake a comprehensive rehabilitation programme to ensure there is no risk of recurrence. This is expected to be approximately six weeks."
Pietersen averages 49.96 in Tests and his absence will make it harder for England to win the five-match series they lead 1-0 following their dramatic 115-run victory over Australia at Lord's on Monday.
Ian Bell will be favourite to replace Pietersen in the team for next week's third Test at Edgbaston. "As an England cricketer the Ashes are the pinnacle of the game so I'm absolutely devastated to be missing the rest of this series," Pietersen said.
"Up until now the Achilles injury has been manageable but it recently reached the point where we needed to look at other options in terms of treatment.
"I hate missing matches for England and especially during an Ashes summer but now that the decision has been made to undergo surgery I'm confident I can return to the England team injury-free following a course of rehabilitation." The South African-born Pietersen has scored 4,647 runs in 54 Tests, including 16 centuries, since making his debut against Australia in 2005.
His brilliant innings of 158 on the last day of the final match of that series enabled England to secure the draw which clinched the Ashes.
Pietersen took over as England captain from Michael Vaughan in 2008 but resigned in January in controversial circumstances after criticising coach Peter Moores.
He top-scored for England with 69 in the first Ashes Test but was widely condemned for the injudicious stroke which caused his dismissal and he looked uncomfortable during the second match when he contributed scratchy knocks of 32 and 44.
The 27-year-old Bell, a right-hander who averages 40.59 in 46 Tests, has been prolific for his county Warwickshire this season and will be the main contender to come into the team.
He played all five Tests in the 2005 Ashes series but struggled against the Australian attack, making only two half centuries in 10 innings.