what's the buzz

what's the buzz

Get rid of smoking without weight gain

Fear of weight gain has always discouraged some smokers who would like to quit. But now, a new study has uncovered a brain mechanism that could be targeted for new medications designed to help people quit smoking without gaining weight.

 In the study researchers found that a nicotine-like drug, cytisine, specifically activated nicotinic receptors in the hypothalamus - a brain centre that controls feeding in rodents.
This resulted in the activation of a circuit that reduced food intake and body fat in a mouse model. This effect was very specific, since a drug that prevented cytisine from binding to its hypothalamic receptors blocked the reduction in food intake.

 Dr Marina Picciotto, Yale University, said “We found that nicotine reduced eating and body fat through receptors implicated in nicotine aversion and withdrawal rather than reward and reinforcement.”
 
Broccoli, cauliflower can kill cancer cells

 Scientists have found that a nutrient present in broccoli, cauliflower and other cruciferous vegetables can selectively target and kill cancer cells while leaving normal prostate cells healthy and unaffected.

The scientists in the Linus Pauling Institute at Oregon State University have shown that sulforaphane found at fairly high levels in these vegetables is an inhibitor of histone deacetylase, or HDAC enzymes.

HDACs are a family of enzymes that, among other things, affect access to DNA and play a role in whether certain genes are expressed or not, such as tumor suppressor genes. HDAC inhibition is one of the more promising fields of cancer treatment and is being targeted from both a pharmaceutical and dietary approach, said scientists.

“It’s important to demonstrate that sulforaphane is safe if we propose to use it in cancer prevention or therapies,” said Emily Ho, the study’s lead author.

“Just because a phytochemical or nutrient is found in food doesn’t always mean its safe, and a lot can also depend on the form or levels consumed. But this does appear to be a phytochemical that can selectively kill cancer cells, and that’s always what you look for in cancer therapies,” Emily stated.

Killer heels could end up giving you arthritis

A study has found that killer heels and ill-fitting footwear could end up giving you arthritis.

According to experts, a staggering 60 per  cent of arthritis affects the feet and is often caused by wearing badly fitting shoes such as stilettos.

Experts have revealed that high heels are prone to altering the body’s posture and increasing the pressure on the foot, ankle and knee joints, thus increasing the risk of osteoarthritis.

Scientists have discovered that 22 per cent of adults believe that arthritis is an inevitable outcome of old age and there is no prevention to it. Research also showed that 77 per cent of both men and women do not wear shoes designed specifically for their chosen sport.  

“Choosing the right footwear will help minimise the stress placed on the feet and joints during everyday activity and help reduce the risk of injury and joint damage. For daily wear, the recommendation is to opt for a round-toed shoe with a heel height of no more than two to three centimetres and with a shock-absorbent sole to help minimise shock to the joints,” he added.

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