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Grape seed extract kills cancer cells

A new study by Indian origin researcher has  revealed that the synthesis of the most active component of grape seed extract, B2G2, encourages the cell death known as apoptosis in prostate cancer cells while leaving healthy cells unharmed.

“We’ve shown similar anti-cancer activity in the past with grape seed extract (GSE), but now we know B2G2 is its most biologically active ingredient which can be synthesized in quantities that will allow us to study the detailed death mechanism in cancer cells,” Alpna Tyagi, PhD, of the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, said.

Previous studies have shown the GSE effectiveness against cancer cells and have also shown its mechanism of action. However, Tyagi said that until recently, they didn’t know which constituent of GSE created this effect. This naturally occurring compound, GSE, is a complex mixture of polyphenols and also so far it has been unclear about the biologically active constituents of GSE against cancer cells.

Eventually the group pinpointed B2G2 as the most active compound, but, “it’s expensive and it takes a long time to isolate B2G2 from grape seed extract,” Tyagi says.

Why better sunscreens are needed

A new study has revealed that even a low level of daily exposure to a common component of sunlight, ultraviolet A1, or UVA1, can cause skin damage at the molecular level after just a few days.

The findings by researchers at University of Michigan Medical School highlighted the need for better sunscreens to protect against these damaging rays, and prevent the process that can cause skin to look old, wrinkled and sagging prematurely.

The researchers showed that damage starts after just two daily exposures to a low amount of ultraviolet A1, or UVA1, light- which makes up most of the UV light we are exposed to throughout the day, and tanning bed light too.

By showing that repeated exposure to the type of UVA1 light that we typically experience on a sunny day causes these damaging processes in the skin, the researchers hope it will lead to the development of new protective ingredients in sunscreens, and more caution about routine sun exposure throughout the day.

Sleep disturbances linked to poor quality of life in obese

A new research has showed that poor sleep quality is strongly associated with mood disturbance and lower quality of life among people with extreme obesity.

Results show that 74.8 percent of participants were poor sleepers, and their mean self-reported sleep duration was only six hours and 20 minutes.

Fifty-two percent of study subjects were anxious, and 43 percent were depressed.  After controlling for age, sex, hypertension, diabetes, and obstructive sleep apnea, sleep quality and daytime sleepiness were significantly associated with mood disturbance and quality of life impairment.

“There was a clear association between the sleep problems such as short sleep duration and the psychological disorders and with quality of life,” Dr. G. Neil Thomas, from the University of Birmingham in the UKingdom, said.

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