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Japanese mushroom extract kills HPV

Researchers have demonstrated that treating cervical cancer cells with Japanese mushroom extract active hexose correlated compound (AHCC) led to the eradication of HPV, human papillomavirus (HPV).

In the study cervical cancer cells were treated with AHCC and incubated for 72 hours with sampling every 24 hours. The study was then repeated in two orthotopic mouse models, one HPV positive and other HPV negative control.

The HPV expression was eradicated with once daily AHCC dosing for 90 days with durable response after 30 day observation off treatment. Dr Judith A Smith, PharmD, at the University of Texas Health Science Centre (UTHealth) Medical School at Houston, then repeated the study to confirm findings and added sampling for correlative testing of immune markers to determine the mechanism by which AHCC eradicates the HPV virus.

These data suggest AHCC can eliminate HPV infections and may have a role in the prevention of HPV-related cancers.

A confirmatory pilot study in HPV+ women is underway at UTHealth Women’s Centre. AHCC works as an immunotherapy, which is a treatment that uses a body’s own immune system to help fight disease.

Human and in-vivo studies have shown that AHCC increases the number and/or activity of Natural Killer (NK) cells, dendritic cells, and cytokines, which enable the body to effectively respond to infections and block the proliferation of tumors.

Genetic cause behind rare type of ovarian cancerResearchers have uncovered the reason behind rare type of ovarian cancer that most often strikes girls and young women.

The findings revealed a “genetic superhighway” mutation in a gene found in the overwhelming majority of patients with small cell carcinoma of the ovary, hypercalcemic type, also known as SCCOHT.

This type of cancer usually is not diagnosed until it is in its advanced stages. It does not respond to standard chemotherapy, and 65 percent of patients die within 2 years. It has affected girls as young as 14 months, and women as old as 58 years — with a mean age of only 24 years old. In this study, the youngest patient was 9 years old.

Dr. Jeffrey Trent, President and Research Director of TGen, and the study’s senior author, added that while the breakthrough is for a relatively rare cancer, discovering the origins of this type of ovarian cancer could have implications for more common diseases. The SMARCA4 gene — previously associated with lung, brain and pancreatic cancer — was the only recurrently mutated gene in the study’s samples. The implications of this discovery, therefore, may be widespread.
Meditation to lessen cancer symptoms among teensResearchers at the University of Montreal, has suggested that mindfulness-based meditation could lessen some symptoms associated with cancer in teens.

Catherine Malboeuf-Hurtubise of the university’s Department of Psychology and her team asked 13 adolescents with cancer to complete questionnaires covering mood (positive and negative emotions, anxiety and depression), sleep and quality of life.

The group was divided in two: a first group of eight adolescents were offered eight mindfulness-based meditation sessions and the remaining five adolescents in the control group were put on a wait-list. The eight sessions were 90 minutes long and took place weekly. After the last meditation session, patients from both groups filled out the same questionnaires a second time.

Differences between both groups were not large enough for the researchers to impute observed benefits solely to the mindfulness component of the sessions.

“The social support provided to the adolescents in the mindfulness group could explain observed benefits on mood and sleep,” Malboeuf-Hurtubise said. “Nonetheless, mindfulness-based interventions for teenagers with cancer appear as a promising option to lighten psychological inconveniences of living with cancer.” The researchers intend to offer members of the control group an opportunity to undertake the meditation sessions.

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