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The drug, minocycline, likely will improve on the current treatment regimens of HIV-infected patients if used in combination with a standard drug cocktail known as HAART (Highly Active Antiretroviral Therapy).
“The powerful advantage to using minocycline is that the virus appears less able to develop drug resistance because minocycline targets cellular pathways not viral proteins,” says Janice Clements and Mary Wallace Stanton.
“The big challenge clinicians deal with now in this country when treating HIV patients is keeping the virus locked in a dormant state,” Clements adds. “While HAART is really effective in keeping down active replication, minocycline is another arm of defence against the virus.”
Unlike the drugs used in HAART which target the virus, minocycline homes in on, and adjusts T cells, major immune system agents and targets of HIV infection.

Sleep deprivation linked to drug use among teens
Poor sleep patterns are likely to drive adolescents at the centre of social networks to use drugs, thereby increasing their vulnerability, says a study.
Researcher Sara C Mednick, University of California, pointed out the spread of one behaviour in social networks — in this case, poor sleep patterns — influences the spread of another behaviour, adolescent drug use.

Mednick said: “This is our first investigation of the spread of illegal drug use in social networks. We believe it is also the first study in any age population on the spread of sleep behaviours through social networks.”
Mednick and colleagues discovered clusters of poor sleep behaviour and marijuana use that extended up to four degrees of separation in the social network.
Mednick explained: “When parents, schools and law enforcement want to look for ways to influence one outcome, such as drug use, our research suggests that targeting another behaviour, like sleep, may have a positive influence. They should be promoting healthy sleep habits that eliminate behaviours which interfere with sleep: take the TV out of the child’s bedroom, limit computer and phone usage to daytime and early evening hours, and promote napping.”

Bone stem cells can be used to mend damaged hips
Bone stem cells could in future be used instead of bone from donors as part of an innovative new hip replacement treatment, according to scientists at the University of Southampton.
A team of researchers believe that introducing a patient’s own skeletal stem cells into the hip joint during bone grafting would encourage more successful regrowth and repair.
The grafting technique is used to repair the thigh bone and joint during replacement (known as ‘revision’) hip replacement therapy, a procedure in which surgeons introduce donor bone to the damaged area to provide support for the new hip stem.
In this collaborative study between the University of Southampton and The University of Nottingham, researchers will use adult stem cells from bone marrow in combination with an innovative impaction process and polymer scaffolds.

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