They are perfecting in developing bare “scaffold building blocks” of body parts which, they said, could be used as a frame for a patient’s own cells to grow around.
Experts said the scaffold for the most commonly used parts could be created in advance and stored ready for use when needed, the “Telegraph” reported.The technique, which has already been successful in creating a new section of windpipe for patients, involves taking a piece of dead donor or animal body part and removing all the soft tissue so just the bare structure is left.
Then, stem cells from the patient can then be placed on the frame and will regrow into a new body part for them, according to the scientists.Prof John Fisher from The University of Leeds said banks of scaffolds of all kinds of body tissue can be created to facilitate doctors in transplants.
Speaking at the UK National Stem Cell Network Annual Science Meeting in Nottingham, Fisher said that he and his team have been working on to create the scaffolds from dead donors or animals.
He said: “If you take a natural tissue and strip off all of the donor’s cells you’re left with a biological scaffold made mostly of a protein called collagen, which is compatible with the patient receiving the scaffold.
“That scaffold is good from an engineering perspective because it’s strong, flexible and retains the properties of the natural tissue. It also has the appropriate shape and size, and from a biological perspective is good because a patient’s cells can bind to it and repopulate it easily.”
According to the scientist, the advantage of the method is that the patient will not reject the transplanted tissue as foreign because the scaffold is stripped of all material that can trigger rejection and the soft tissue is grown from their own stem cells. It means patients can avoid powerful immunosurpressant drugs which shorten life expectancy and can increase the risk of cancer, he said.
He said chemically treated and strengthened prosthetic heart valves from pigs, for example, have been used in human transplants for more than a decade, but the chemical process which stops them from being rejected by the patient’s immune system also leaves them lifeless so they degrade over time and need to be replaced.