<p>Six-time champion Novak Djokovic was sent spinning out of the Italian Open on Thursday, losing his quarter-final 6-2, 4-6, 6-2 to 20-year-old Holger Rune in Rome on Wednesday.</p>.<p>The young Dane whistled through the first set as the 35-year-old Serb appeared to be struggling physically.</p>.<p>Djokovic was treated by the physio at 2-1 in the second set but went on to level the match before Rune produced a double break at the top of the third, going on to book his place in the semi-final.</p>
<p>Six-time champion Novak Djokovic was sent spinning out of the Italian Open on Thursday, losing his quarter-final 6-2, 4-6, 6-2 to 20-year-old Holger Rune in Rome on Wednesday.</p>.<p>The young Dane whistled through the first set as the 35-year-old Serb appeared to be struggling physically.</p>.<p>Djokovic was treated by the physio at 2-1 in the second set but went on to level the match before Rune produced a double break at the top of the third, going on to book his place in the semi-final.</p>