The incident occurred near Takhtabaig security check post in Khyber Agency, situated a few kilometres away from Peshawar, the capital of the North West Frontier Province.
An explosion occurred when an oil tanker was hit by a roadside bomb.
The blast triggered a fire that destroyed two tankers and gutted a few shops, said Muhammad Siddique, an official of the political administration of Khyber Agency.
Four persons injured by the blaze were taken to a nearby government hospital.
No group claimed responsibility for the attack.
Local militants from the Lashkar-e-Islam have attacked trucks and tankers carrying supplies to US and NATO forces in Afghanistan in the past.
Nearly 75 per cent of oil and food supplies and military hardware for foreign troops in Afghanistan passes through the Khyber Agency.
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