Press Esc to close
Saturday 01 August 2015
News updated at 7:12 PM IST
Weather
Max: 29.9°C
Min : 21°C
In Bengaluru
Generally cloudy
Breaking News

Bangalore scientists claim breakthrough in Alzheimer's drug

Kalyan Ray, Bhubaneswar, Jan 5, DHNS:

Clinical trials of Ayurvedic medicine on humans pending

Vijayalakshmi Ravindranath

Bangalore scientists have demonstrated a complete cure for Alzheimer’s in mice in one month using a plant extract used in Ayurvedic system of medicine, opening up a new window of hope for thousands of human Alzh­eimer patients.

The researchers from the Indian Institute of Science, Bangalore, were brimming with excitement. The herbal extract administered to Alzheimer's-affected mice produced “dramatic improvements” in 21 days and “after 30 days they were no different from normal mice,” said Vijayalakshmi Ravindranath, professor and chair at the Centre for Neuroscience, IISc, presenting her latest findings at the Indian Science Congress here.

Even though they have patented the herbal formulation, the scientists do not want to disclose the plant's name.

The breakthrough, to be published shortly in a leading scientific journal, may lead to a new treatment for Alzhe­imer's disease once scien­tists determine the dose and undertake a proper toxicology and human clinical trial, which would take a few years.
Alzheimer’s disease affects higher cognitive functions, including causing trouble with language and long-term memory loss. It is one of the two commonest neurodegenerative disorders, which has no treatment at the moment.

Doctors offer symptomatic treatment, which is akin to using anacin for headache without knowing the cause of the headache. India currently has a whopping 3.7 million Alzh­eimer’s patients whose numbers are expected to double.

The IISc team was inspired to explore the potential of the herb used in Ayurveda by P K Warrior, a 90-year-old practitioner of Indian System of Medicine from famous Arya Vaidya Sala, Kottakkal in Kerala.

In a laboratory set-up, trained mice can easily pick up food offered as a bait, but a mouse with Alzheimer’s disease never learns the ability. When mice aged between 10 months to 24 months were given the herbal extract orally for 30 days, the results were dramatic. “For mouse the dose was 1 gm per kilogram of body weight, which is on a higher side. It was a semi-purified compound that was used in animal trials. For humans, we want to further purify the compound to lower the dose further,” she told Deccan Herald.

In Alzheimer’s patients, the amount of a protein called A-beta increases abnormally and creates plaques in the form of sheets in brain tissues. The herbal extract can suck out the plaques completely even when administered orally.


Go to Top

Photo Gallery
A farmer plants saplings in a paddy field on the outskirts of in Agartala...

A farmer plants saplings in a paddy field on the outskirts of in Agartala...

Leopard caught in forest department cage at CSIR premises, Manadavadi Road in Mysuru on Friday...

Leopard caught in forest department cage at CSIR premises, Manadavadi Road in Mysuru on Friday...

Actress Chitrangada Singh during the inauguration of a diamond showroom in Bengaluru on Friday...

Actress Chitrangada Singh during the inauguration of a diamond showroom in Bengaluru on Friday...

Artists from Gujarat perform a dance at the Travel and Tourism Fair at Netaji Indoor Stadium...

Artists from Gujarat perform a dance at the Travel and Tourism Fair at Netaji Indoor Stadium...

A woman prays as others take holy dips at Sangam, the confluence of the Rivers Ganges...

A woman prays as others take holy dips at Sangam, the confluence of the Rivers Ganges...

School children pay tribute to former President APJ Abdul Kalam in Gurgaon on Friday...

School children pay tribute to former President APJ Abdul Kalam in Gurgaon on Friday...

Securitymen guard parliament house during the monsoon session in New Delhi on Friday...

Securitymen guard parliament house during the monsoon session in New Delhi on Friday...

Congress Vice President Rahul Gandhi meeting agitating students of FTII...

Congress Vice President Rahul Gandhi meeting agitating students of FTII...

Dukhtaran-e-Millat activists holding placards during their protest against the hanging of Yakub...

Dukhtaran-e-Millat activists holding placards during their protest against the hanging of Yakub...

Policemen in action after a clash between BJP workers and AIIMS coordination committee members...

Policemen in action after a clash between BJP workers and AIIMS coordination committee members...

Copyright 2014, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523