Press Esc to close

Body clock disruption can cause diabetes and heart attack

Washington, Feb 22, 2013, (PTI) : 18:02 IST
Disruption in the body clock or circadian rhythm can not only cause obesity, but also increase the risk of diabetes and heart attacks, a new study has found.

That is the conclusion of the first study to show definitively that insulin activity is controlled by the body's circadian biological clock.

The study, published in the journal Current Biology, helps explain why not only what you eat, but when you eat, matters.

The study was conducted by a team of Vanderbilt scientists led by Carl Johnson, Owen McGuinness and David Wasserman.

"Our study confirms that it is not only what you eat and how much you eat that is important for a healthy lifestyle, but when you eat is also very important," said researcher postdoctoral fellow Shu-qun Shi.

In recent years, a number of studies in both mice and men have found a variety of links between the operation of the body's biological clock and various aspects of its metabolism, the physical and chemical processes that provide energy and produce, maintain and destroy tissue.

It was generally assumed that these variations were caused in response to insulin, which is one of the most potent metabolic hormones.

However, no one had actually determined that insulin action follows a 24-hour cycle or what happens when the body's circadian clock is disrupted.

Because they are nocturnal, mice have a circadian rhythm that is the mirror image of that of humans: They are active during the night and sleep during the day.

Scientists have found that the internal timekeeping system of the two species operate in nearly the same way at the molecular level.

Most types of cells contain their own molecular clocks, all of which are controlled by a master circadian clock in the suprachiasmatic nucleus in the brain.

"People have suspected that our cells' response to insulin had a circadian cycle, but we are the first to have actually measured it. The master clock in the central nervous system drives the cycle and insulin response follows," said McGuinness in a statement.

Go to Top

Photo Gallery
CPI(M) workers chant slogans at a protest rally outside BJP headquarters in New Delhi on Tuesday...

CPI(M) workers chant slogans at a protest rally outside BJP headquarters in New Delhi on Tuesday...

Woman teachers pose with Diwali greeting messages at a school in Moradabad on Tuesday...

Woman teachers pose with Diwali greeting messages at a school in Moradabad on Tuesday...

A girl buying decorative items in a market on the occasion of Dhanteras festival in Bhopal on ...

A girl buying decorative items in a market on the occasion of Dhanteras festival in Bhopal on ...

Vendors show lanterns to customers at a roadside market ahead of the Hindu festival of Diwali in ...

Vendors show lanterns to customers at a roadside market ahead of the Hindu festival of Diwali in ...

BJP National President Amit Shah and BJP Kerala state president Kummanam Rajasekharan wave to the ..

BJP National President Amit Shah and BJP Kerala state president Kummanam Rajasekharan wave to the ..

England Midfielder Callum Hudson-Odoi(14) and Hinata Kida(6),Midfielder of Japan vie for the ball ..

England Midfielder Callum Hudson-Odoi(14) and Hinata Kida(6),Midfielder of Japan vie for the ball ..

Actress and BJP MP Hema Malini along with her daughters Ahana and Esha cutting a cake to celebrate..

Actress and BJP MP Hema Malini along with her daughters Ahana and Esha cutting a cake to celebrate..

Union Minister for Defence, Nirmala Sitharaman with Chief of Naval Staff, Admiral Sunil Lanba and ..

Union Minister for Defence, Nirmala Sitharaman with Chief of Naval Staff, Admiral Sunil Lanba and ..

Kamaraj Congress (KKC) and Most Backward Communities Federation demonstrators lying on the road in..

Kamaraj Congress (KKC) and Most Backward Communities Federation demonstrators lying on the road in..

Rajesh Talwar arrives at his residence in Noida on Monday after he, along with his wife Nupur, was..

Rajesh Talwar arrives at his residence in Noida on Monday after he, along with his wife Nupur, was..

Like us on Facebook

Copyright 2017, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523
Powered by Yodasoft Technologies Pvt. Ltd.