Press Esc to close
Thursday 21 August 2014
News updated at 3:35 PM IST
Weather
Max: 30.8°C
Min : 20.7°C
In Bangalore
Generally cloudy

Migraine sufferers may have brain abnormalities

Washington, Apr 2, 2013, (PTI):

Migraines are related to brain abnormalities present at birth and others that develop over time, a new study suggests.

Patients who suffer from migraines have reduced cortical thickness and surface area in pain-processing regions of the brain, compared to individuals who never have migraines, Italian researchers found.

More than 300 million people suffer from migraines worldwide, according to the World Health Organisation.


In the new study, researchers used a surface-based MRI method to measure cortical thickness.

"For the first time, we assessed cortical thickness and surface area abnormalities in patients with migraine, which are two components of cortical volume that provide different and complementary pieces of information," said Massimo Filippi, director of the Neuroimaging Research Unit at the University Ospedale San Raffaele.

"Indeed, cortical surface area increases dramatically during late foetal development as a consequence of cortical folding, while cortical thickness changes dynamically throughout the entire life span as a consequence of development and disease," Filippi said in a RSNA statement.

Filippi and colleagues used magnetic resonance imaging (MRI) to acquire T2-weighted and 3-D T1-weighted brain images from 63 migraine patients and 18 healthy controls.
Compared to controls, migraine patients showed reduced cortical thickness and surface area in regions related to pain processing, the journal Radiology reported.

There was only minimal anatomical overlap of cortical thickness and cortical surface area abnormalities, with cortical surface area abnormalities being more pronounced and distributed than cortical thickness abnormalities.

The presence of aura and white matter hyperintensities - areas of high intensity on MRI that appear to be more common in people with migraine - was related to the regional distribution of cortical thickness and surface area abnormalities, but not to disease duration and attack frequency.

"The most important finding of our study was that cortical abnormalities that occur in patients with migraine are a result of the balance between an intrinsic predisposition, as suggested by cortical surface area modification, and disease-related processes, as indicated by cortical thickness abnormalities," Filippi said.

"Whether the abnormalities are a consequence of the repetition of migraine attacks or represent an anatomical signature that predisposes to the development of the disease is still debated.

Go to Top

Photo Gallery
Boy plays with a dog near idols of elephant-headed Hindu god Ganesha, displayed for sale by a...

Boy plays with a dog near idols of elephant-headed Hindu god Ganesha, displayed for sale by a...

Pakistan football team players after defeating India on their second match at  KSFA Stadium ...

Pakistan football team players after defeating India on their second match at KSFA Stadium ...

Dejected Indian football team players after their loss during the 2nd International U-23 Friendly...

Dejected Indian football team players after their loss during the 2nd International U-23 Friendly...

Director Rajkumar Hirani right, and producer Vidhu Vinod Chopra, left, enjoy a lighter moment as...

Director Rajkumar Hirani right, and producer Vidhu Vinod Chopra, left, enjoy a lighter moment as...

Former Prime Minister Manmohan Singh with Congress President Sonia Gandhi at the Rajiv Gandhi...

Former Prime Minister Manmohan Singh with Congress President Sonia Gandhi at the Rajiv Gandhi...

Actor Rani Mukherjee with Mumbai Police Commissioner Rakesh Maria during the launch of Women Beat...

Actor Rani Mukherjee with Mumbai Police Commissioner Rakesh Maria during the launch of Women Beat...

President Pranab Mukherjee and Congress President Sonia Gandhi look on as Congress party Vice ...

President Pranab Mukherjee and Congress President Sonia Gandhi look on as Congress party Vice ...

Bollywod actress Mandira Bedi during the inauguration of a painting exhibition in Mumbai on ...

Bollywod actress Mandira Bedi during the inauguration of a painting exhibition in Mumbai on ...

A man gets his shave done by a roadside barber as another reads a newspaper while waiting for...

A man gets his shave done by a roadside barber as another reads a newspaper while waiting for...

A model at a promotional event of Rado watches in Lucknow  ...

A model at a promotional event of Rado watches in Lucknow ...

Copyright 2014, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bangalore - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523