Srinivasan, who played for India in one Test and two one-dayers in 1980-81, was 60 and is survived by wife and a daughter, family sources said.
He was suffering from the dreaded disease for a long time and breathed his last at a city hospital this morning.
Srinivasan, a key player for Tamil Nadu in the 70s, totalled 48 runs in his debut Test, against New Zealand in March 1981.
During his first class career, he had played 75 matches, including 45 in Ranji Trophy, and scored 3,487 runs at an average of 34.18 with five centuries.
An occasional leg-spinner, he represented Woodhouse in the Yorkshire League for some years, and also played Grade cricket in New South Wales.
Tamil Nadu Cricket Association (TNCA) president N Srinivasan expressed grief over the death of the former cricketer.
Deccan Herald is on WhatsApp Channels| Join now for Breaking News & Editor's Picks