Murray, who last year became the first Briton to win the title in 71 years, kicked off his grasscourt campaign with a 7-6, 6-3 win over Spaniard Ivan Navarro while Roddick was at his ruthless best in a 6-2, 6-1 demolition of Russia's Igor Kunitsyn.
Third seed Murray initially seemed taken aback at the sight of a serve-and-volleying Spaniard but once he had got over that shock he found his groove to book a place in the third round. Sixth seed Gael Monfils went down 6-3, 6-7, 6-2 to Germany's Rainer Schuettler.
A one-hour rain break at 6-6 in the second set offered Monfils some respite, as on resumption he won the tiebreak 7-4, but the elastic-limbed Frenchman eventually bounced out.
His compatriot Richard Gasquet avoided the same fate with a 6-3, 7-5 win over American Rajeev Ram.
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