The strike took place at about 10 a.m. and the target was a house suspected of being a hideout of militants in a hilly area of Jandola, reported Xinhua citing a TV channel.
Identities of the dead was not immediately known.
On Tuesday morning, the US drones launched a strike in the neighbouring tribal area of North Waziristan, killing seven suspected militants.
A total of 524 people, most of whom are believed to be suspected militants, have reportedly been killed in such strikes so far this year.
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