Press Esc to close
Thursday 26 May 2016
News updated at 8:08 AM IST
Weather
Max: 34°C
Min : 22.7°C
In Bengaluru
Partially cloudy

Indian researchers see leads in developing Aids vaccine

Kalyan Ray, New Delhi, Dec 16, 2013, DHNS:
AP Photo

Indian researchers have stumbled upon a handful of early leads in their pursuit of a vaccine against HIV, but it would probably take decades before these leads are translated into a commercial vaccine against Aids.

Analysing blood samples of 128 HIV positive persons, a group of young Indian scientists found four “neutralising antibodies” that can block entry of the human immunodeficiency virus in a human cell. Scientists are analysing if any one of these four antibodies or a combination of them can be used as a vaccine against HIV.

“We have seen good signals in four samples. But more research needs to be conducted,” said Bimal Chakraborty, who heads the group at the International Aids Vaccine Initiative laboratory at the Translational Health Science and Technology Institute, here that got the leads.

The research is a part of Protocol-G, a scientific programme to fish out such neutralising antibodies (a type of protein) from blood samples of HIV infected individual.

The researchers received 200- blood samples from Chennai based non-governmental organisation YRG Care led by Suniti Solomon, who reported the first HIV case in India in the 1980s.

“Out of 200 samples, we studied 128 samples so far and will complete the rest by the first quarter of 2014. By the end of next year, we hope to find out which one of these leads are worth pursuing further,” Rajat Goyal, IAVI country director told Deccan Herald.

IAVI and its partners have isolated a number of antibodies from HIV positive donors from around the world. Researchers believe that these antibodies hold vital clues to the design of an effective AIDS vaccine.

The agency recently launched the Indian arm of Protocol-G to identify such antibodies from Indian samples infected by the Indian strain, known as Clade-C sub-type of HIV.

Notwithstanding the failure of several candidate HIV vaccines in clinical trials, scientists said there were few major advancements in the last one year that would provide better insight into vaccine development.

“At least two laboratories have identified the outer protein of the virus and made its crustal structure. We know there are four vulnerable spots,” said Wayne C Koff, IAVI chief scientific officer.

“We will examine if the Indian proteins are acting against these four vulnerable sites on the outer shell of the virus or is there a fifth or sixth vulnerable spot,” said Koff, an adjunct professor in the State University of New York, Stony Brook.


Go to Top

Photo Gallery
Girls cover themselves during a dust storm in mathura on Monday...

Girls cover themselves during a dust storm in mathura on Monday...

Renowned sand artist Sudarsan Pattnaik creates a sand art to aware people about water scarcity...

Renowned sand artist Sudarsan Pattnaik creates a sand art to aware people about water scarcity...

English actor Sir Ian McKellen and Bollywood actor Aamir Khan share lighter moments...

English actor Sir Ian McKellen and Bollywood actor Aamir Khan share lighter moments...

A senior Army Officer presents the Sher-e-Kashmir Sword of Honour to a new recruit...

A senior Army Officer presents the Sher-e-Kashmir Sword of Honour to a new recruit...

People watching the air ambulance which crash landed at Kair village in Najafgarh area...

People watching the air ambulance which crash landed at Kair village in Najafgarh area...

Demi Moore poses for photographers as she arrives for The Vogue 100 Gala Dinner...

Demi Moore poses for photographers as she arrives for The Vogue 100 Gala Dinner...

Nuremberg and Frankfurt players jump for the ball during a German first division Bundesliga soccer..

Nuremberg and Frankfurt players jump for the ball during a German first division Bundesliga soccer..

People hang fish to dry on bamboo poles in Mumbai...

People hang fish to dry on bamboo poles in Mumbai...

A cyclist with his daughter pedals his cycle holding an umbrella...

A cyclist with his daughter pedals his cycle holding an umbrella...

An elderly vendor waits for customers of green grass during rains in Srinagar....

An elderly vendor waits for customers of green grass during rains in Srinagar....

Copyright 2014, The Printers (Mysore) Private Ltd., 75, M.G Road, Post Box 5331, Bengaluru - 560001
Tel: +91 (80) 25880000 Fax No. +91 (80) 25880523