Williams, 44, would take over as station commander at the International Space Station that was her home in the sky from Dec 9, 2006 to June 22, 2007.
She will be joined on the Soyuz 31 flight to the space station by flight engineers Russian cosmonaut Yuri Malenchenko and Japanese astronaut Akihiko Hoshide, the space agencies of the three nations announced Friday.
Daughter of Gujarat born neuroanatomist Deepak Pandya and Slovak mother Bonnie Pandya, Williams was born in Euclid, Ohio, but considers Needham, Massachusetts where her parents live as her hometown.
After launching aboard Discovery, Williams arranged to donate her pony tail to Locks of Love. Fellow astronaut Joan Higginbotham cut her hair aboard the International Space Station and the Discovery crew brought the ponytail back to earth.
Among the personal items Williams took with her on her last trip were a copy of the Bhagavad Gita, a small figurine of Ganesha and some samosas. The question is what would she carry this time around.