<p>The team, from KAIST University, South Korea and LG Chem, led by Sang Yup Lee, professor, focused on polylactic acid (PLA), a bio-based polymer, the key to producing plastics through renewable resources. <br />"The polyesters and other polymers we use every day are mostly derived from fossil oils made through the refinery or chemical process," said Lee. <br />"PLA is considered a good alternative to petroleum based plastics as it is both biodegradable and has a low toxicity to humans," he added.<br />Until now PLA has been produced in a two-step fermentation and polymerisation, which is both complex and expensive. <br />Now, through the use of a metabolically engineered strain of E. coli, the team has produced polylactic acid and its co-polymers through direct fermentation. <br />This makes the renewable production of PLA and lactate-containing copolymers cheaper and more commercially viable, said a KAIST University release.<br />"By developing a strategy which combines metabolic engineering and enzyme engineering, we've developed an efficient bio-based one-step production process for PLA and its copolymers," said Lee. <br />"This means that a developed E. coli strain is now capable of efficiently producing unnatural polymers, through a one-step fermentation process." <br />These findings were published in Biotechnology and Bioengineering.</p>
<p>The team, from KAIST University, South Korea and LG Chem, led by Sang Yup Lee, professor, focused on polylactic acid (PLA), a bio-based polymer, the key to producing plastics through renewable resources. <br />"The polyesters and other polymers we use every day are mostly derived from fossil oils made through the refinery or chemical process," said Lee. <br />"PLA is considered a good alternative to petroleum based plastics as it is both biodegradable and has a low toxicity to humans," he added.<br />Until now PLA has been produced in a two-step fermentation and polymerisation, which is both complex and expensive. <br />Now, through the use of a metabolically engineered strain of E. coli, the team has produced polylactic acid and its co-polymers through direct fermentation. <br />This makes the renewable production of PLA and lactate-containing copolymers cheaper and more commercially viable, said a KAIST University release.<br />"By developing a strategy which combines metabolic engineering and enzyme engineering, we've developed an efficient bio-based one-step production process for PLA and its copolymers," said Lee. <br />"This means that a developed E. coli strain is now capable of efficiently producing unnatural polymers, through a one-step fermentation process." <br />These findings were published in Biotechnology and Bioengineering.</p>