<p>Bengaluru: Scientists at the Institute for Stem Cell Science Regenerative Medicine in Bengaluru have identified a new gene that could be one of the reasons for cardiomyopathy, a condition leading to sudden heart attacks.</p>.<p>Dr Dhandapany Perundurai and his team at the institute screened roughly 20,000 to 25,000 genes in Indian patients with primary cardiomyopathy. His team discovered that a new gene called Tubulin Tyrosine Ligase (TTL) is one such reason for the unexplained condition, which claims the lives of many youngsters. </p>.<p>Cardiomyopathy results in the failure of the left ventricles (typically), which is caused by the thickening of the heart wall. </p>.<p>A single mutation or undesirable change in a gene leads to abnormal proteins and leads to irregular heart beat. The team identified an amino acid called glycine that was replaced by another amino acid called serine in the TTL protein.</p>.<p>“Mutation may be due to exposure to pollution, UV rays and are heritable and can happen to anyone. During physical activities, there is a higher chance of failure, ending in sudden death,” Dr Perundurai told <span class="italic">DH</span>.</p>.Our eyes are key to early diagnosis of heart disease, Alzheimer's: Research.<p>The experiment followed a stem cell module. Blood samples of TTL patients with cardiomyopathy were taken. Blood cells were converted to 2D stem cell cultures and then to a beating heart cell, which replicates the human heart beat, allowing scientists to see where the problem lies. Reconstruction of ventricles is also done through 3D organoids to replicate the heart structure.</p>.<p>The team edited glycine to serine in the controlled sample. It was found that normal heart cells became diseased and were beating irregularly, indicating that the mutation was the sole reason for the disease.</p>.<p>Cut-off box - How can we avoid the mutation? "In the practical sense the mutation is tough to avoid. However genetic testing every five years can help with identifying mutations and customised medicine for the mutation can be prescribed." Dr Dhandapany Perundurai.</p>
<p>Bengaluru: Scientists at the Institute for Stem Cell Science Regenerative Medicine in Bengaluru have identified a new gene that could be one of the reasons for cardiomyopathy, a condition leading to sudden heart attacks.</p>.<p>Dr Dhandapany Perundurai and his team at the institute screened roughly 20,000 to 25,000 genes in Indian patients with primary cardiomyopathy. His team discovered that a new gene called Tubulin Tyrosine Ligase (TTL) is one such reason for the unexplained condition, which claims the lives of many youngsters. </p>.<p>Cardiomyopathy results in the failure of the left ventricles (typically), which is caused by the thickening of the heart wall. </p>.<p>A single mutation or undesirable change in a gene leads to abnormal proteins and leads to irregular heart beat. The team identified an amino acid called glycine that was replaced by another amino acid called serine in the TTL protein.</p>.<p>“Mutation may be due to exposure to pollution, UV rays and are heritable and can happen to anyone. During physical activities, there is a higher chance of failure, ending in sudden death,” Dr Perundurai told <span class="italic">DH</span>.</p>.Our eyes are key to early diagnosis of heart disease, Alzheimer's: Research.<p>The experiment followed a stem cell module. Blood samples of TTL patients with cardiomyopathy were taken. Blood cells were converted to 2D stem cell cultures and then to a beating heart cell, which replicates the human heart beat, allowing scientists to see where the problem lies. Reconstruction of ventricles is also done through 3D organoids to replicate the heart structure.</p>.<p>The team edited glycine to serine in the controlled sample. It was found that normal heart cells became diseased and were beating irregularly, indicating that the mutation was the sole reason for the disease.</p>.<p>Cut-off box - How can we avoid the mutation? "In the practical sense the mutation is tough to avoid. However genetic testing every five years can help with identifying mutations and customised medicine for the mutation can be prescribed." Dr Dhandapany Perundurai.</p>