In its special issue that hits newsstands on Friday, People also singled out stars and non-stars alike with special titles. Brad Pitt and Angelina Jolie were named "Glam Parents," and the Chilean miners were singled out for their dramatic rescue.
But Bullock graces the cover for making it through her up-and-down year. The 46 year-old actress won the best actress Oscar for "The Blind Side" in March, but about one week later her joy turned to heartache with sensational headlines that her husband Jesse James had cheated on their marriage.
In April, it was revealed that she and James had previously adopted a baby boy. By June, the pair were divorced and Bullock had custody of the child. Then, in August, financial website Forbes.com declared her the highest paid actress in Hollywood who earned $56 million for two box office hits, football film "The Blind Side" and romantic comedy "The Proposal."
Other names included in the 2010 list were actress Natalie Portman, given the title "Screen Gem," for her risky role as a ballerina in Oscar-hopeful film "Black Swan."
Female rapper Nicki Minaj was named "Rap Renegade," and upcoming Oscar co-host and actor James Franco, who this year has starred in movies, released a book and had his own art exhibit, was labeled "Multitasker" in the list.
Conservative politician Sarah Palin was dubbed the "Big Gun" of 2010.
People also highlights celebrity marriages, separations and a "Hall of Shame" that reviews the year's celebrity lows, including actor Mel Gibson's domestic abuse investigation.