Human DNA has hundreds of flaws

Normal healthy people on average have 400 flaws in their DNA, some of which are linked to cancer and heart disease in later life while others can cause problems when passed to future generations, a new study has claimed.

UK geneticists said that most flaws are “silent” mutations and do not affect health, although they can cause problems when passed to future generations.

Others are linked to conditions such as cancer or heart disease, which appear in later life, say geneticists.

The evidence comes from the 1,000 Genomes project, which is mapping normal human genetic differences, from tiny changes in Deoxyribonucleic acid (DNA) to major mutations, the BBC News reported. In the study, 1,000 seemingly healthy people from Europe, the Americas and East Asia had their entire genetic sequences decoded, to look at what makes people different from each other, and to help in the search for genetic links to diseases.

The new research, published in The American Journal of Human Genetics, compared the genomes of 179 participants, who were healthy at the time their DNA was sampled, with a database of human mutations developed at Cardiff University.

It revealed that a normal healthy person has on average about 400 potentially damaging DNA variations, and two DNA changes known to be associated with disease.
“Ordinary people carry disease-causing mutations without them having any obvious effect,” said Dr Chris Tyler-Smith, lead researcher on the study from the Wellcome Trust Sanger Institute, Cambridge.