<p>In a breakthrough, an Indian- American scientist at the prestigious MIT has developed a simple, cheap, paper test that could improve cancer diagnosis rates and help people get treated earlier.<br /><br /></p>.<p>The diagnostic, which works much like a pregnancy test, could reveal within minutes, based on a urine sample, whether a person has cancer, the Massachusetts Institute of Technology (MIT) announced yesterday.<br /><br />This approach has helped detect infectious diseases, and the new technology allows non-communicable diseases to be detected using the same strategy, it said.<br /><br />The technology, developed by MIT professor and Howard Hughes Medical Institute investigator 46-year-old Sangeeta Bhatia, relies on nanoparticles that interact with tumour proteins called proteases, each of which can trigger release of hundreds of biomarkers that are then easily detectable in a patient's urine.<br /><br />"When we invented this new class of synthetic biomarker, we used a highly specialised instrument to do the analysis," says Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science.<br /><br />"For the developing world, we thought it would be exciting to adapt it instead to a paper test that could be performed on unprocessed samples in a rural setting, without the need for any specialized equipment. The simple readout could even be transmitted to a remote caregiver by a picture on a mobile phone," Bhatia said in a statement.<br /><br />Bhatia, a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science, is the senior author of a paper describing the particles in the Proceedings of the National Academy of Sciences published this week.<br /><br />The paper's lead authors are graduate student Andrew Warren, postdoc Gabriel Kwong, and former postdoc David Wood.</p>
<p>In a breakthrough, an Indian- American scientist at the prestigious MIT has developed a simple, cheap, paper test that could improve cancer diagnosis rates and help people get treated earlier.<br /><br /></p>.<p>The diagnostic, which works much like a pregnancy test, could reveal within minutes, based on a urine sample, whether a person has cancer, the Massachusetts Institute of Technology (MIT) announced yesterday.<br /><br />This approach has helped detect infectious diseases, and the new technology allows non-communicable diseases to be detected using the same strategy, it said.<br /><br />The technology, developed by MIT professor and Howard Hughes Medical Institute investigator 46-year-old Sangeeta Bhatia, relies on nanoparticles that interact with tumour proteins called proteases, each of which can trigger release of hundreds of biomarkers that are then easily detectable in a patient's urine.<br /><br />"When we invented this new class of synthetic biomarker, we used a highly specialised instrument to do the analysis," says Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science.<br /><br />"For the developing world, we thought it would be exciting to adapt it instead to a paper test that could be performed on unprocessed samples in a rural setting, without the need for any specialized equipment. The simple readout could even be transmitted to a remote caregiver by a picture on a mobile phone," Bhatia said in a statement.<br /><br />Bhatia, a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science, is the senior author of a paper describing the particles in the Proceedings of the National Academy of Sciences published this week.<br /><br />The paper's lead authors are graduate student Andrew Warren, postdoc Gabriel Kwong, and former postdoc David Wood.</p>