After drubbing the visitors 3-0 in the Test series, the hosts now lead the ODIs 4-0 with the final match to be played at Perth on Sunday.
Spurred by half-centuries from Michael Hussey (67) and Nathan Hauritz (53 n.o.), Australia posted a challenging 277 for eight in 50 overs.
Pace bowler Ryan Harris then tore through the Pakistani batting with a second successive five-for as the World T20 champions collapsed to 142 all out in 37.5 overs. Harris picked up five for 19 to walk away with a second man-of-the-match award in as many matches.
SCORE BOARD
Australia
Marsh c K Akmal b Asif 12
Haddin b Rana Naved 32
Ponting c K Akmal b S Afridi 30
Clarke (run out) 10
White c Asif b Ajmal 44
Hussey c Yousuf b Ajmal 67
Hopes b Asif 16
Hauritz (not out) 53
Harris c Afridi b Asif 4
McKay (not out) 0
Extras (lb-2, W-6, nb-1) 9
Total (for 8 wkts, 50 overs) 277
Fall of wickets: 1-30, 2-55, 3-77, 4-110, 5-159, 6-190, 7-270, 8-275.
Bowling: Asif 10-1-42-3, Rana Naved 10-0-70-1, Anjum 10-0-64-0, Afridi 10-1-44-1, Ajmal 10-0-55-2.
Pakistan
Butt c White b Harris 0
K Akmal c Haddin b Siddle 17
Younis c Haddin b Harris 6
Yousuf c Haddin b Siddle 10
U Akmal b Harris 38
Alam (run out) 21
Afridi c Hauritz b McKay 29
Rana Naved c Haddin b Harris 0
Anjum c Haddin b Harris 5
Ajmal b Hauritz 7
Asif (not out) 0
Extras (lb-5, W-3, nb-1) 9
Total (all out, 37.5 overs) 142
Fall of wickets: 1-2, 2-14, 3-38, 4-39, 5-99, 6-125, 7-125, 8-131, 9-140.
Bowling: Harris 9.5-3-19-5, Siddle 6-0-31-2, McKay 7-2-16-1, Hopes 7-0-23-0, Hauritz 8-0-48-1.
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