How caffeine affects brain receptors

How caffeine affects brain receptors

How caffeine affects brain receptors

Scientists have visualised the binding sites of caffeine in the brain for the first time to help understand the link between caffeine and neurodegenerative disorders like Alzheimer’s.

German researchers using molecular imaging with positron emission tomography (PET) found that repeated intake of caffeinated beverages throughout a day results in up to 50 per cent occupancy of the brain’s A1 adenosine receptors.

“The effects of caffeine to the human body are generally attributed to the cerebral adenosine receptors. In the human brain the A1 adenosine receptor is the most abundant,” said David Elmenhorst, lead author of the study.

“In vitro studies have shown that commonly consumed quantities of caffeine have led to a high A1 adenosine occupancy. Our study aimed to measure the A1 adenosine receptor occupancy with in vivo imaging,” Elmenhorst said in a statement.

Fifteen male volunteers participated in the study. They abstained from caffeine intake for 36 hours and then underwent a PET scan with F-18-CPFPX.

Caffeine was then introduced in short intravenous infusions, increasing in amount. To estimate the occupancy of A1 adenosine receptors by caffeine, the distribution volume at the baseline period of the PET scan was compared with the distribution volume after caffeine administration.

Researchers determined that the concentration of the caffeine that displaces 50 per cent of the binding of F-18-CPFPX to the A1 adenosine receptor was approximately four to five cups of coffee.

An important finding of the study was that in most regular coffee drinkers about half of the A1 adenosine receptors may be occupied by caffeine.

It is likely that this blockage of a substantial amount of cerebral A1 adenosine receptors will result in adaptive changes and lead to chronic alterations of receptor express and availability.

“There is substantial evidence that caffeine is protective against neurodegenerative diseases like Parkinson’s or Alzheimer’s disease,” noted Elmenhorst.

“Several investigations show that moderate coffee consumption of 3 to 5 cups per day at mid-life is linked to a reduced risk of dementia in late life,” Elmenhorst said.

“The present study provides evidence that typical caffeine doses result in a high A1 adenosine receptor occupancy and supports the view that the A1 adenosine receptor deserves broader attention in the context of neurodegenerative disorders,” Elmenhorst added.

The study was published in the Journal of Nuclear Medicine.

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