Skipper Aaron Finch and Steve Smith blazed centuries and Josh Hazlewood ripped apart the Indian top order as Australia won by 66 runs in the first one-day international at the Sydney Cricket Ground on Friday.
The Indians, coming out of coronavirus quarantine, looked rusty in their first taste of international cricket since February, as the Australians went on a run rampage to reach 374 for six after winning the toss.
Hazlewood then put the skids under the tourists, triggering a top-order wobble. Among his victims was coveted wicket of skipper Virat Kohli, as India amassed 308 for eight in reply.
Australia enjoyed perfect batting conditions. Finch belted 114 and shared an opening stand of 156 with David Warner, who made 69 off 75 balls.
Smith had some early luck early before taking charge and hitting 105 off 66 balls with four sixes.
He was saved by DRS after a confident appeal for leg before wicket on 15. Then Shikhar Dhawan badly missed Smith's miscue on 38 at long on.
After Finch raised his 17th ODI century he was out for 114 off 124 balls trying to steer a Jasprit Bumrah lifter behind the wicket in the 40th over.
Glenn Maxwell hit a rumbustious 45 off 19 balls as Australia built a massive total to defend under the evening lights.
India made a fast start, the openers flaying the Aussie attack for 53 before Mayank Agarwal fell to Hazlewood for 22.
Kohli was dropped on one by Adam Zampa at fine leg after top-edging a Pat Cummins lifter.
The reprieve did not last long when the India skipper was cramped by Hazlewood and found Finch at mid-wicket, his night over at 21.
Two balls later, Hazlewood picked up Shreyas Iyer, failing to get his bat away from a bouncer and skying to Alex Carey for two, leaving the tourists at 80 for three.
Shikhar Dhawan and Hardik Pandya gave India an outside hope of pulling off victory in a 128-run partnership before Dhawan was caught by Mitchell Starc off Zampa for 74.
India's remaining hope went with Pandya who took on Zampa but failed to clear the rope and was caught by Starc for 90 off 76 balls. Zampa finished with four for 54 off his 10 overs.
India had not played international cricket since a tour of New Zealand earlier in the year and it showed with their outfielding ragged at times.
In contrast, Australia came into the match on the back of beating 50-over world champions England in September.
Even getting to the opening toss was an uphill battle for India, with wrangling over quarantine requirements and a recent outbreak of coronavirus in Melbourne complicating matters.
But Cricket Australia was desperate for the blockbuster tour, which also includes four Tests, to go ahead, with the funds generated crucial after the sport was hit hard by the Covid-19 shutdown.
Before play, both teams formed a ceremonial, barefoot circle to acknowledge the traditional indigenous owners of the SCG land.
Both teams also observed a minute's silence for the passing of Australia batting great Dean Jones, who died of a heart attack in India last September.