India’s First Ayurvedic Psoriasis Cream Clinically Proven to Lower IL-23: A Breakthrough in Steroid-Free Psoriasis Care

New Delhi, India, June 9, 2025: In a landmark development for chronic skin health in India, VedicDerm, a doctor-led Ayurvedic skincare startup, has launched a breakthrough psoriasis treatment: India’s first Ayurvedic psoriasis cream clinically validated to reduce IL-23 and IL-17, two immune biomarkers at the heart of the psoriasis inflammatory process.

While most over-the-counter psoriasis creams rely heavily on topical steroids or immunosuppressants, VedicDerm’s formulation is 100% steroid-free, yet backed by rigorous in vitro testing conducted at an NABL-accredited laboratory.

The Science Behind This Psoriasis Treatment

Psoriasis is a chronic autoimmune skin condition that causes the skin to regenerate abnormally fast. This leads to red, scaly, itchy patches that may crack or bleed. It can affect the scalp, elbows, knees, nails, and in more severe cases, even joints, leading to psoriatic arthritis.

The core drivers of this condition lie in an overactive immune system, particularly along the IL-23/IL-17 cytokine pathway.

“If you lower IL-23 and IL-17, you slow down the inflammatory loop that drives psoriasis,” explains Dr. Samyak Dhawan, physician and founder of VedicDerm. “This is the first time an Ayurvedic formulation has demonstrated measurable downregulation of these cytokines—without steroids.”

In third-party lab testing using HaCaT cell lines and 3D-cultured epidermal tissue models, VedicDerm’s best psoriasis cream showed the following results:

-       99% reduction in Substance P (linked to psoriasis flare-ups)levels

-       91% reduction in Histamine (a biomarker for itching)

-       90% reduction in IL-23

-       74% reduction in IL-17 levels

These results were achieved without using corticosteroids or synthetic immunosuppressants, making it a potential game-changer in Ayurvedic treatment for psoriasis.

The Hidden Dangers of Long-Term Steroid Use

Conventional psoriasis creams often rely on corticosteroids to suppress symptoms quickly. While these may offer short-term relief, prolonged use comes with side effects like skin thinning (atrophy), steroid rebound flare-ups (when stopped), photosensitivity, increased risk of infections, and hormonal disruption in children and elderly patients.

Over time, patients often find themselves dependent on steroid creams, needing more substantial doses for the same relief, which weakens the skin barrier and exacerbates the underlying condition.

VedicDerm’s approach is different—it offers a safe, long-term alternative for those seeking steroid-free psoriasis management.

Clinically Relevant Herbal Ingredients

The cream’s efficacy lies in its synergistic formulation of Ayurvedic herbs, known not just for their tradition but also for their scientific validation. Effective herbs include Manjishtha (Rubia cordifolia), Mulethi (Glycyrrhiza glabra), Aloe Vera, Neem Oil, Tea Tree Oil, and Babchi (Psoralea corylifolia).  These herbs are delivered in a non-comedogenic, barrier-friendly base that enhances skin absorption without irritation.

Safety Profile and Suitability

VedicDerm’s psoriasis cream passed all cytotoxicity and tissue integrity tests, making it suitable for long-term daily use, flare-up management during seasonal changes, and patients tapering off steroid-based regimens or having sensitive skin.

Unlike steroid-based treatments, this cream does not cause skin thinning, dependency, or withdrawal symptoms. It is safe to use on the face, scalp, and intimate areas, where steroid use is often discouraged.

The cream is used to treat psoriasis, which often creates thick, red skin plaques with silvery-white scaling, itching and burning, dry, cracked and bleeding skin with changes on the nail, and painful, swollen joints in psoriatic arthritis.

VedicDerm’s best psoriasis treatment is ideal for managing these symptoms, especially for patients seeking a long-term, steroid-free solution.

Shifting the Paradigm: Evidence-Based Ayurveda

The launch of this product signals a paradigm shift in integrative dermatology, where Ayurveda and science converge rather than collide.

“You no longer need to choose between tradition and evidence,” says Dr. Dhawan. “We aim to build Ayurveda’s future on data, not dogma—and that’s exactly what this cream represents.”

Availability

You can now buy VedicDerm’s Ayurvedic treatment for psoriasis online via:

🌐 www.vedicderm.com
 🛒 Amazon, Flipkart, and select dermatology clinics

This product is a must-have in every household battling chronic skin issues. Whether searching for the best psoriasis cream, a natural psoriasis oil, or a holistic psoriasis treatment plan, VedicDerm offers an honest, effective, and steroid-free alternative.