JOIN USHussey, 35, injured his left hamstring while taking a second run in Australia's six-wicket victory in the opening match of the seven-game ODI series in Melbourne yesterday.
"Scans today have confirmed that Mike Hussey sustained a significant left hamstring injury during the first ODI against England at the MCG," Australia's physiotherapist Alex Kountouris said.
"The course of management for this injury will be determined in the next 24 hours."
Shane Watson, who scored a match-winning unbeaten 161 to guide Australia to victory, said Hussey appeared okay at the time of his setback.
"I think he's got a little bit of hammy stiffness, I probably pushed him one too many to (Paul) Collingwood," Watson said after the match.
"He seemed to be okay, there was no real talk about a runner, I think he's alright."
Hussey's injury comes as Australia's squad for next month's World Cup on the sub-continent is to be announced on tomorrow.