<p>A chemical compound commonly found in coffee may help prevent weight gain and also fight some obesity-related diseases, finds new research.<br /><br /></p>.<p>The compound called chlorogenic acid, or CGA, significantly reduced insulin resistance and accumulation of fat in the livers of mice who were fed a high-fat diet, the findings showed.<br />"CGA is a powerful antioxidant that reduces inflammation," said study lead author Yongjie Ma from UGA.<br /><br />Aside from weight gain, two common side effects of obesity are increased insulin resistance and the accumulation of fat in the liver. <br /><br />Researchers fed a group of mice a high-fat diet for 15 weeks while also injecting them with a CGA solution twice per week.<br /><br />They found that CGA was not only effective in preventing weight gain, but it also helped maintain normal blood sugar levels and healthy liver composition.<br /><br />The mice in this study received a high dose of CGA, much higher than what a human would absorb through regular coffee consumption or a diet rich in fruits and vegetables.<br /><br />The mice in this study received a high dose of CGA, much higher than what a human would absorb through regular coffee consumption or a diet rich in fruits and vegetables.<br />"We are not suggesting that people start drinking a lot of coffee to protect themselves from an unhealthy lifestyle," Ma stressed.<br /><br />"But we do think that we might be able to create a useful therapeutic using CGA that will help those at risk for obesity-related disease as they make positive lifestyle changes."<br />The study appeared in the journal Pharmaceutical Research.<br /></p>
<p>A chemical compound commonly found in coffee may help prevent weight gain and also fight some obesity-related diseases, finds new research.<br /><br /></p>.<p>The compound called chlorogenic acid, or CGA, significantly reduced insulin resistance and accumulation of fat in the livers of mice who were fed a high-fat diet, the findings showed.<br />"CGA is a powerful antioxidant that reduces inflammation," said study lead author Yongjie Ma from UGA.<br /><br />Aside from weight gain, two common side effects of obesity are increased insulin resistance and the accumulation of fat in the liver. <br /><br />Researchers fed a group of mice a high-fat diet for 15 weeks while also injecting them with a CGA solution twice per week.<br /><br />They found that CGA was not only effective in preventing weight gain, but it also helped maintain normal blood sugar levels and healthy liver composition.<br /><br />The mice in this study received a high dose of CGA, much higher than what a human would absorb through regular coffee consumption or a diet rich in fruits and vegetables.<br /><br />The mice in this study received a high dose of CGA, much higher than what a human would absorb through regular coffee consumption or a diet rich in fruits and vegetables.<br />"We are not suggesting that people start drinking a lot of coffee to protect themselves from an unhealthy lifestyle," Ma stressed.<br /><br />"But we do think that we might be able to create a useful therapeutic using CGA that will help those at risk for obesity-related disease as they make positive lifestyle changes."<br />The study appeared in the journal Pharmaceutical Research.<br /></p>