Macedonian striker Goran Pandev slotted in a scuffed shot from Samuel Eto'o after six minutes to grab his third goal since rejoining Inter last month.
Defender Walter Samuel then powered in a header from a corner and Argentina's Diego Milito netted his 14th goal of the league campaign after a fine move just after the break.
AS Roma stole second place from AC Milan thanks to a fortunate 1-0 win at mid-table Fiorentina, who were denied by a tight offside call when Juan Vargas netted and spurned several other chances. The visitors snatched victory when Mirko Vucinic fired in off the bar following a corner eight minutes from time.
Milan failed to win for the fourth consecutive game in a 0-0 draw at struggling Bologna.
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