Know your cells

VITAL SIGNS

Know your cells

It’s often said that the bacteria and other microbes in our body outnumber our own cells by about 10 to 1. That’s a myth that should be forgotten, say researchers in Israel and Canada. The ratio between resident microbes and human cells is more likely to be one-to-one, they calculate.

A “reference man” (one who is 70 kilograms, or about 154 pounds, 20–30 years old and 1.7 metres, or about 5 feet 7 inches tall) contains on average about 30 trillion human cells and 39 trillion bacteria, say Ron Milo and Ron Sender at the Weizmann Institute of Science in Rehovot, Israel, and Shai Fuchs at the Hospital for Sick Children in Toronto, Canada.
Those numbers are approximate — another person might have half as many or twice as many bacteria, for example — but far from the 10:1 ratio commonly assumed. “The numbers are similar enough that each defecation event may flip the ratio to favour human cells over bacteria,” they delicately conclude in a manuscript posted to the preprint server bioRxiv.

The 10:1 myth persisted from a 1972 estimate by microbiologist Thomas Luckey, which was “elegantly performed, yet was probably never meant to be widely quoted decades later,” say the paper’s authors. In 2014, molecular biologist Judah Rosner at the US National Institutes of Health at Bethesda, expressed his doubts about the 10:1 claim, noting that there were very few good estimates for the numbers of human and microbial cells in the body.

Researchers decided to re-estimate the number by reviewing a wide range of recent experimental data in the literature, including DNA analyses to calculate cell number and magnetic-resonance imaging to calculate organ volume. The vast majority of human cells are red blood cells, they note.


NYT

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