New gel to speed healing

 Despite repeated surgery, antibiotics, steroids and other treatments, nothing helped.

Then last year, she took part in a trial for a new gel aimed at chronic wounds.
“It was the answer to my prayers,” said McPherson. Within weeks, McPherson said the ulcer treated was completely healed. “I tried everything possible and this is the only thing that worked.”

The gel used to treat McPherson was developed by a team led by David Becker, a professor of cell and developmental biology at University College London. The gel, named Nexagon, works by interrupting how cells communicate and prevents the production of a protein that blocks healing. That allows cells to move faster to the wound to begin healing it.

Though it has only been tested on about 100 people so far, experts say if it proves successful, the gel could have a major impact on treating chronic wounds, like leg or diabetes ulcers, and even common scrapes or injuries from accidents.

In most chronic wounds, Becker said there is an abnormal amount of a protein involved in inflammation.

To reduce its amount, Becker and colleagues made Nexagon from bits of DNA that can block the protein’s production. “As that protein is turned off, cells move in to close the wound,” Becker said. The gel is clear and has the consistency of toothpaste.

In an early study on leg ulcers, scientists at the company Becker co-founded to develop the gel found that after four weeks, the number of people with completely healed ulcers was five times higher in patients who got the gel versus those who didn’t. The average leg ulcer takes up to six months to heal and 60 per cent of patients get repeated ulcers.
Other experts said the gel appeared promising. “It looks like the gel has a good effect in getting the outer layer (of skin) to restore itself,” said Phil Stephens, head of tissue engineering and repair at Cardiff University. Still, Stephens said it is crucial the gel doesn’t interfere too much with the inflammation process.

The gel has also been used on a handful of people who have suffered serious chemical burns to their eyes, including a 25-year-old workman in New Zealand who accidentally squirted liquid cement into one of his eyes. In that case and five others, after Nexagon was applied, the outer lining of the patient’s eyes and the blood vessels within them regrew, saving their vision. In the US, the gel has been granted approval by the Food and Drug Administration for serious eye injuries.

“This gel has the potential to do a lot of good,” said Dr. Thomas Serena, founder and director of the Penn North Centers for Advanced Wound Care in Pennsylvania. Serena has no financial ties to Nexagon, but is one of the primary investigators for a US trial of the product.

For McPherson, the experience of being treated with Nexagon was so positive she asked to be included in the gel's next trial, to treat an even larger ulcer that wasn’t eligible for the first study.

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