JOIN USRoddick, Berdych floored
In the women's draw, defending champion Kim Clijsters and former champion Venus Williams dazzled their opponents and charmed the crowds after Victoria Azarenka had sent a shiver through the tennis world when she fainted on court.
Roddick was outplayed by unseeded Serb Janko Tipsarevic but his 3-6, 7-5, 6-3, 7-6 defeat was reduced to a footnote after the ninth seed's churlish rant with a line judge over a footfault that had no bearing on the result.
Much earlier in the day, it was a tumble on one of the outside courts that sent pulses racing at the year's last Grand Slam.
Azarenka, in a black dress and playing when temperatures were at their hottest, was rushed to hospital after collapsing in a heap at the baseline during her second round match against Argentina's Gisela Dulko.
The Belarussian had succumbed to scorching heat at last year's Australian Open and there were fears she had been a victim of the extreme temperatures that had forced US Open organisers to invoke their rarely used Extreme Weather Policy.
She later revealed that she had been diagnosed with a mild concussion and her frightening crumble was a delayed reaction to a fall suffered earlier in the gym while warming up. "I was checked by the medical team before I went on court and they were courtside for monitoring," said Azarenka, who was trailing 5-1 in the first set when she collapsed.
"I felt worse as the match went on, having a headache and feeling dizzy. I also started having trouble seeing and felt weak before I fell."
Murray showed why he is regarded as a serious contender to capture the men's title as he crushed Slovakia's Lukas Lacko 6-3, 6-2, 6-2.
The perennial hope of British tennis, Murray succeeded in escaping the worst of the roasting heat by racing to victory in under two hours. "I managed to get through in straight sets so I'm pleased, but it was a lot tougher than the score suggests," the fourth-seeded Scot said. "Everyone in my (supporters) box always tell me it's a lot tougher watching in the heat than playing but I'm not so sure. It was brutal conditions."
Although the weather was slightly cooler than the previous day, it was still hot enough to leave players drenched in sweat and calling for ice packs to drape around their necks at the change of ends.
New York's hottest summer in decades has spilled on to the courts at Flushing Meadows and contributed to a high dropout rate among the seeds.
Another eight seeds made early exits on Day Three, giving the main contenders extra incentive to quickly kill off their opponents.
Clijsters, who won the hearts of the crowds last year with her infant daughter watching from the stands, showed no mercy in her centre court clash against Australian qualifier Sally Peers, who once pinned a photo of the Belgian on her bedroom wall.
"I'm just trying every match to grow so I'm ready when the opponents get tougher," Clijsters said after thumping her inexperienced opponent 6-2, 6-1 in less than an hour.
Williams had no room for sentiment either as she romped to a comfortable 7-6, 6-3 victory over Canada's Rebecca Marino, who gave the third seed a brief scare in the opening set before succumbing to the American's power. Williams is only playing singles this year after her sister and regular doubles partner Serena pulled out with an injury and said she was loving the lighter workload.
"So far I feel good. I made a quick turnaround this summer to try to get ready for the Open," she said.
Williams has not won the US Open title since 2001 but she now represents the host nation's best hope of a champion after Roddick, the highest-ranked American male, bowed out.
Italy's French Open champion Francesca Schiavone and Australia's Samantha Stosur, the woman she beat in the Paris final, both advanced to the third round in straight sets while the other most notable casualty in the men's draw was Wimbledon finalist Tomas Berdych.
The Czech stumbled at the first hurdle, outclassed 7-6, 6-4, 6-4 by France's Michael Llodra, who is better known as a doubles specialist.
Bhupathi-Mirnyi advance
India’s Mahesh Bhupathi and Max Mirnyi of Belarus advanced to the second round of the men’s doubles category.
The fourth-seeded pair of Bhupathi and Mirnyi dispatched Frenchmen Arnaud Clement and Nicolas Mahut 6-1, 6-4 and will play Argentina’s Eduardo Schwank and Horacio Zeballos in their second round encounter.
However, it was the end of the road for India’s Rohan Bopanna and China’s Zi Yan in the mixed doubles category as they lost 2-6, 4-6 to France’s Aravane Rezai and American Rajeev Ram in the first round.
(Prefix denotes seeding): Men, round II: Janko Tipsarevic (Serb) bt 9-Andy Roddick (US) 3-6, 7-5, 6-3, 7-6 (7-4); 17-Gael Monfils (Fra) bt Igor Andreev (Rus) 6-3, 6-4, 6-3.
Round I: 18-John Isner (US) bt Frederico Gil (Por) 6-4, 6-3, 6-4; Dudi Sela (Isr) bt Xavier Malisse (Bel) 7-6 (7-1), 7-5, 6-2; Marco Chiudinelli (Sui) bt Jack Sock (US) 6-1, 6-4, 1-6, 6-1; 29-Philipp Kohlschreiber (Ger) bt Tobias Kamke (Ger) 6-2, 4-6, 6-2, 6-4; 12-Mikhail Youzhny (Rus) bt Andrey Golubev (Kaz) 6-2, 6-3, 6-3; Gilles Simon (Fra) bt Donald Young (US) 6-1, 6-4, 6-2; Juan Ignacio Chela (Arg) bt Lu Yen-Hsun (Twn) 6-4, 4-6, 6-3, 6-3; 25-Stanislas Wawrinka (Sui) bt Mikhail Kukushkin (Kaz) 6-3, 6-2, 6-2; 4-Andy Murray (Bri) bt Lukas Lacko (Slo) 6-3, 6-2, 6-2; Sergiy Stakhovsky (Ukr) bt Peter Luczak (Aus) 6-7 (8-10), 7-5, 6-4, 6-2; Michael Llodra (Fra) bt 7-Tomas Berdych (Cze) 7-6 (7-3), 6-4, 6-4; Ryan Harrison (US) bt 15-Ivan Ljubicic (Cro) 6-3, 6-7 (4-7), 6-3, 6-4; Marcel Granollers (Spa) bt Andreas Seppi (Ita) 2-6, 5-7, 6-3, 6-2, 6-3; 14-Nicolas Almagro (Spa) bt Potito Starace (Ita) 4-6, 6-4, 6-4, 7-6 (7-5); 20-Sam Querrey (US) bt Bradley Klahn (US) 6-3, 4-6, 7-5, 6-4; Guillermo Garcia-Lopez (Spa) bt Lukasz Kubot (Pol) 6-3, 6-2, 7-6 (7-4); Victor Hanescu (Rom) bt Carlos Berlocq (Arg) 6-2, 6-4, 6-3.
Women, round II: 16-Shahar Peer (Isr) bt Pauline Parmentier (Fra) 6-2, 6-3; 2-Kim Clijsters (Bel) bt Sally Peers (Aus) 6-2, 6-1; 27-Petra Kvitova (Cze) bt Elena Baltacha (Bri) 7-6 (7-5), 6-3; 5-Samantha Stosur (Aus) bt Anastasia Rodionova (Aus) 6-1, 6-4; 19-Flavia Pennetta (Ita) bt Agnes Szavay (Hun) 6-1, 6-4; 29-Alona Bondarenko (Ukr) bt Melanie Oudin (US) 6-2, 7-5; 3-Venus Williams (US) bt Rebecca Marino (Can 7-6 (7-3), 6-3; 24-Daniela Hantuchova (Slo) bt Vania King (US) 5-7, 6-3, 6-4; 12-Elena Dementieva (Rus) bt Sybille Bammer (Aut) 6-3, 6-4; 6-Francesca Schiavone (Ita) bt Maria Elena Camerin (Ita) 6-2, 6-1; Virginie Razzano (Fra) bt 13-Marion Bartoli (Fra) 7-5, 6-4; 20-Anastasia Pavlyuchenkova (Rus) bt Sania Mirza (Ind) 6-2, 6-4; Ana Ivanovic (Serb) bt 21-Zheng Jie (Chn) 6-3, 6-0; Gisela Dulko (Arg) bt 10-Victoria Azarenka (Blr) 5-1 (retd).