Large-scale drug analysis reveals potential new Covid-19 antivirals

Francis Crick institute and university of Dundee have screened thousands of drug and chemical molecules and identified a range of potential antivirals that could be developed into new treatments for Covid-19 or in preparation for future coronavirus outbreaks.

Scientists identified 15 molecules that inhibit the growth of SARS-CoV-2 by blocking different enzymes involved in its replication. The tests were based on fluorescent changes with a special imaging tool detecting if enzymes has been affected, and validated accordingly.

While Covid-19 vaccines are being rolled out, there are still few drug options that can be used to treat patients with the virus, reduce symptoms and speed up recovery time. These treatments are especially important for groups where the vaccines are less effective, such as some patients with blood cancer.

The 15 molecules were also tested in combination with remdesivir, an antiviral being used to treat patients with Covid-19.